A novel method to detect bacterial resistance to disinfectants

In clinical practice, the important hygienic prevention of bacterial pathogen spread is disinfection of potentially contaminated area. Benzalkonium bromide and chlorhexidine acetate are commonly used disinfectants with a broad spectrum of anti-microbial effect. It is vital to inhibit the spread of p...

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Bibliographic Details
Published in:Genes & diseases 2017-09, Vol.4 (3), p.163-169
Main Authors: He, Xiao-Feng, Zhang, Hui-Jie, Cao, Jin-Gui, Liu, Fang, Wang, Jian-Kang, Ma, Wen-Jie, Yin, Wen
Format: Article
Language:English
Subjects:
Clinical technology
Disinfectants resistance
Inhibitory efficacy
Oxford plate method
Staphylococcus aureus
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Summary:In clinical practice, the important hygienic prevention of bacterial pathogen spread is disinfection of potentially contaminated area. Benzalkonium bromide and chlorhexidine acetate are commonly used disinfectants with a broad spectrum of anti-microbial effect. It is vital to inhibit the spread of pathogen in hospital. However, a large number of pathogens with the decreased antiseptic susceptibility have been isolated from clinical samples which showed an increased minimal inhibitory concentration (MIC) against those antiseptics. These resistant pathogens are the major causes for nosocomial cross-infections in hospital. The present study demonstrated the utility of Oxford plate assay system in determining the potential disinfectant resistance of bacteria. The microbiological assay is based on the inhibitory effect of tested disinfectants upon the strains of Staphylococcus aureus and Escherichia coli. Statistical analysis of the bioassay results indicated the linear correlation (r = 0.87–0.99, P 
ISSN:2352-3042
2352-4820
2352-3042
DOI:10.1016/j.gendis.2017.07.001