Glomerulonephritis associated with tuberculosis: A case report and literature review

Abstract Rapidly progressive glomerulonephritis caused mycobacterium tuberculosis is rare; however, three case have been reported to date. Crescentic glomerulonephritis is a life-threatening disease and together with the presence of tuberculous infection is associated with a poor outcome if treatmen...

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Bibliographic Details
Published in:The Kaohsiung journal of medical sciences 2013-06, Vol.29 (6), p.337-342
Main Authors: Solak, Yalcin, Gaipov, Abduzhappar, Anil, Melih, Atalay, Huseyin, Ozbek, Orhan, Turkmen, Kultigin, Polat, Ilker, Turk, Suleyman
Format: Article
Language:English
Subjects:
Adult
Anti-tuberculosis treatment
Antitubercular agents
Biopsy
Crescentic glomerulonephritis
Disease Progression
Female
Glomerulonephritis
Glomerulonephritis - etiology
Health aspects
Hospitalization
Humans
Immunoglobulin G
Internal Medicine
Kidney - pathology
Pulmonary tuberculosis
Radiography, Thoracic
Renal failure
Tuberculosis - complications
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Summary:Abstract Rapidly progressive glomerulonephritis caused mycobacterium tuberculosis is rare; however, three case have been reported to date. Crescentic glomerulonephritis is a life-threatening disease and together with the presence of tuberculous infection is associated with a poor outcome if treatment is inadequate and delayed. We describe the case of a 31-year-old female patient with nephrotic syndrome and progressive renal failure secondary to pulmonary tuberculosis. Renal biopsy showed crescent formation in 14 out of 27 glomeruli, and there was diffuse linear staining of immunoglobulin G deposits. Treatment included corticosteroids in combination with antituberculosis drugs for 2 months, and resulted in a significant improvement in renal function, the disappearance of proteinuria and pulmonary symptoms. We also present a review of the pertinent literature and discuss the pathophysiology of tuberculosis-related acute postinfectious glomerulonephritis.
ISSN:1607-551X
2410-8650
DOI:10.1016/j.kjms.2012.10.008