Honey: A Promising Therapeutic Supplement for the Prevention and Management of Osteoporosis and Breast Cancer

Osteoporosis and breast cancer are serious diseases that have become a significant socioeconomic burden. There are biochemical associations between the two disorders in terms of the amended function of estrogen, receptor activator of nuclear factor kappa beta ligand, oxidative stress, inflammation,...

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Published in:Antioxidants 2023-02, Vol.12 (3), p.567
Main Authors: Martiniakova, Monika, Kovacova, Veronika, Mondockova, Vladimira, Zemanova, Nina, Babikova, Martina, Biro, Roman, Ciernikova, Sona, Omelka, Radoslav
Format: Article
Language:English
Subjects:
Anti-inflammatory agents
Antioxidants
Apoptosis
associations
Breast cancer
Cell proliferation
Chronic illnesses
Clinical trials
Cytokines
Enzymes
Estrogens
Fibroblasts
Fractures
Growth rate
Health aspects
Honey
Inflammation
Interleukin 3
Kinases
Ligands
Menopause
Mortality
Osteoporosis
Oxidative stress
Polyphenols
preclinical studies
Prevention
Quality of life
Review
Tumor necrosis factor-TNF
Womens health
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Summary:Osteoporosis and breast cancer are serious diseases that have become a significant socioeconomic burden. There are biochemical associations between the two disorders in terms of the amended function of estrogen, receptor activator of nuclear factor kappa beta ligand, oxidative stress, inflammation, and lipid accumulation. Honey as a functional food with high antioxidant and anti-inflammatory properties can contribute to the prevention of various diseases. Its health benefits are mainly related to the content of polyphenols. This review aims to summarize the current knowledge from in vitro, animal, and human studies on the use of honey as a potential therapeutic agent for osteoporosis and breast cancer. Preclinical studies have revealed a beneficial impact of honey on both bone health (microstructure, strength, oxidative stress) and breast tissue health (breast cancer cell proliferation and apoptosis, tumor growth rate, and volume). The limited number of clinical trials, especially in osteoporosis, indicates the need for further research to evaluate the potential benefits of honey in the treatment. Clinical studies related to breast cancer have revealed that honey is effective in increasing blood cell counts, interleukin-3 levels, and quality of life. In summary, honey may serve as a prospective therapeutic supplement for bone and breast tissue health.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox12030567