Photoredox-Catalyzed Acylation/Cyclization of 2-Isocyanobiaryls with Oxime Esters for the Synthesis of 6-Acyl Phenanthridines

An efficient acylation/cyclization reaction of 6-acyl phenanthridines with oxime esters using photoredox catalysis has been developed. This radical acyl transfer strategy enables a facile access to acyl-substituted phenanthridines with good yield and excellent selectivity. The developed method is re...

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Bibliographic Details
Published in:Catalysts 2022-11, Vol.12 (11), p.1446
Main Authors: Tang, Boxiao, Ding, Chuan, Ou, Min, Liu, Yu, Liu, Junwei, Liu, Yilin
Format: Article
Language:English
Subjects:
2-isocyanobiaryls
Acylation
Antifungal agents
Catalysts
Chemical reactions
Chemical synthesis
domino reactions
Esters
Functional groups
Nitrogen
oxime esters
phenanthridines
photocatalysis
Photoredox catalysis
Selectivity
Solvents
Substrates
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Summary:An efficient acylation/cyclization reaction of 6-acyl phenanthridines with oxime esters using photoredox catalysis has been developed. This radical acyl transfer strategy enables a facile access to acyl-substituted phenanthridines with good yield and excellent selectivity. The developed method is redox neutral and has broad substrate scope and excellent functional group tolerance.
ISSN:2073-4344
2073-4344
DOI:10.3390/catal12111446