Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering

Hydrogels have been extensively used as scaffolds in tissue engineering for cell adhesion, proliferation, migration, and differentiation because of their high-water content and biocompatibility similarity to the extracellular matrix. However, submicron or nanosized pore networks within hydrogels sev...

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Bibliographic Details
Published in:Gels 2022-09, Vol.8 (10), p.606
Main Authors: Ma, Yuan, Wang, Xinhui, Su, Ting, Lu, Feng, Chang, Qiang, Gao, Jianhua
Format: Article
Language:English
Subjects:
biochemical cues
Biocompatibility
Blood & organ donations
Cell adhesion
cell behaviors
Ethylenediaminetetraacetic acid
Heparan sulfate
Hydrogels
macroporous hydrogels
matrix mechanics
Mechanical properties
Medical research
Metabolites
Moisture content
Peptides
Polymers
Pore size
Regeneration (physiology)
Review
Tissue engineering
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Summary:Hydrogels have been extensively used as scaffolds in tissue engineering for cell adhesion, proliferation, migration, and differentiation because of their high-water content and biocompatibility similarity to the extracellular matrix. However, submicron or nanosized pore networks within hydrogels severely limit cell survival and tissue regeneration. In recent years, the application of macroporous hydrogels in tissue engineering has received considerable attention. The macroporous structure not only facilitates nutrient transportation and metabolite discharge but also provides more space for cell behavior and tissue formation. Several strategies for creating and functionalizing macroporous hydrogels have been reported. This review began with an overview of the advantages and challenges of macroporous hydrogels in the regulation of cellular behavior. In addition, advanced methods for the preparation of macroporous hydrogels to modulate cellular behavior were discussed. Finally, future research in related fields was discussed.
ISSN:2310-2861
2310-2861
DOI:10.3390/gels8100606