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The Combination of Binding Avidity of Ovomucoid-Specific IgE Antibody and Specific IgG4 Antibody Can Predict Positive Outcomes of Oral Food Challenges during Stepwise Slow Oral Immunotherapy in Children with Hen's Egg Allergy
To increase the prediction accuracy of positive oral food challenge (OFC) outcomes during stepwise slow oral immunotherapy (SS-OIT) in children with a hen's egg (HE) allergy, we evaluated the predictive value of the combination of antigen-specific IgE (sIgE) with antigen binding avidity and sIg...
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Published in: | Nutrients 2023-06, Vol.15 (12), p.2770 |
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creator | Taniuchi, Shoichiro Sakai, Rika Nishida, Takahiro Goma, Meguru Mitomori, Masatoshi Imaide, Aya Enomoto, Masahiro Nishino, Masamitsu Okizuka, Yo Kido, Hiroshi |
description | To increase the prediction accuracy of positive oral food challenge (OFC) outcomes during stepwise slow oral immunotherapy (SS-OIT) in children with a hen's egg (HE) allergy, we evaluated the predictive value of the combination of antigen-specific IgE (sIgE) with antigen binding avidity and sIgG4 values. Sixty-three children with HE allergy undergoing SS-OIT were subjected to repeated OFCs with HE. We measured the ovomucoid (OVM)-sIgE by ImmunoCAP or densely carboxylated protein (DCP) microarray, sIgG4 by DCP microarray, and the binding avidity of OVM-sIgE defined as the level of 1/IC
(nM) measured by competitive binding inhibition assays. The OFC was positive in 37 (59%) patients undergoing SS-OIT. Significant differences in DCP-OVM-sIgE, CAP-OVM-sIgE, I/IC
, DCP-OVM-sIgG4, the multiplication products of DCP-OVM-sIgE, and the binding avidity of DCP-OVM-sIgE (DCP-OVM-sIgE/IC
) and DCP-OVM-sIgE/sIgG4 were compared between the negative and positive groups (
< 0.01). Among them, the variable with the greatest area under the receiver operating characteristic curve was DCP-OVM-sIgE/IC
(0.84), followed by DCP-OVM-sIgE/sIgG4 (0.81). DCP-OVM-sIgE/IC
and DCP-OVM-sIgE/sIgG4 are potentially useful markers for the prediction of positive OFCs during HE-SS-OIT and may allow proper evaluation of the current allergic status in the healing process during HE-SS-OIT. |
doi_str_mv | 10.3390/nu15122770 |
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(nM) measured by competitive binding inhibition assays. The OFC was positive in 37 (59%) patients undergoing SS-OIT. Significant differences in DCP-OVM-sIgE, CAP-OVM-sIgE, I/IC
, DCP-OVM-sIgG4, the multiplication products of DCP-OVM-sIgE, and the binding avidity of DCP-OVM-sIgE (DCP-OVM-sIgE/IC
) and DCP-OVM-sIgE/sIgG4 were compared between the negative and positive groups (
< 0.01). Among them, the variable with the greatest area under the receiver operating characteristic curve was DCP-OVM-sIgE/IC
(0.84), followed by DCP-OVM-sIgE/sIgG4 (0.81). DCP-OVM-sIgE/IC
and DCP-OVM-sIgE/sIgG4 are potentially useful markers for the prediction of positive OFCs during HE-SS-OIT and may allow proper evaluation of the current allergic status in the healing process during HE-SS-OIT.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu15122770</identifier><identifier>PMID: 37375671</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Allergens ; Allergies ; Animals ; Asthma ; Avidity ; Binding ; Biomarkers ; Chickens ; Children ; Drug dosages ; Egg Hypersensitivity - therapy ; Eggs ; Female ; Food allergies ; Food allergy ; hen’s egg allergy ; IgE binding avidity ; Immunoglobulin E ; Immunoglobulin G ; Immunoglobulins ; Immunotherapy ; Informed consent ; oral food challenge ; oral immunotherapy ; Ovomucin ; ovomucoid-specific IgE ; ovomucoid-specific IgG4 ; Patients ; Prognosis ; Protein arrays ; Supervision</subject><ispartof>Nutrients, 2023-06, Vol.15 (12), p.2770</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c499t-8c7959c81fbbb8946b963370dd468626be482765ce0f4673fe0d7bbeaa5066e13</cites><orcidid>0009-0005-0397-7559 ; 0000-0002-6369-3428</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2829845360/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2829845360?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37375671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taniuchi, Shoichiro</creatorcontrib><creatorcontrib>Sakai, Rika</creatorcontrib><creatorcontrib>Nishida, Takahiro</creatorcontrib><creatorcontrib>Goma, Meguru</creatorcontrib><creatorcontrib>Mitomori, Masatoshi</creatorcontrib><creatorcontrib>Imaide, Aya</creatorcontrib><creatorcontrib>Enomoto, Masahiro</creatorcontrib><creatorcontrib>Nishino, Masamitsu</creatorcontrib><creatorcontrib>Okizuka, Yo</creatorcontrib><creatorcontrib>Kido, Hiroshi</creatorcontrib><title>The Combination of Binding Avidity of Ovomucoid-Specific IgE Antibody and Specific IgG4 Antibody Can Predict Positive Outcomes of Oral Food Challenges during Stepwise Slow Oral Immunotherapy in Children with Hen's Egg Allergy</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>To increase the prediction accuracy of positive oral food challenge (OFC) outcomes during stepwise slow oral immunotherapy (SS-OIT) in children with a hen's egg (HE) allergy, we evaluated the predictive value of the combination of antigen-specific IgE (sIgE) with antigen binding avidity and sIgG4 values. Sixty-three children with HE allergy undergoing SS-OIT were subjected to repeated OFCs with HE. We measured the ovomucoid (OVM)-sIgE by ImmunoCAP or densely carboxylated protein (DCP) microarray, sIgG4 by DCP microarray, and the binding avidity of OVM-sIgE defined as the level of 1/IC
(nM) measured by competitive binding inhibition assays. The OFC was positive in 37 (59%) patients undergoing SS-OIT. Significant differences in DCP-OVM-sIgE, CAP-OVM-sIgE, I/IC
, DCP-OVM-sIgG4, the multiplication products of DCP-OVM-sIgE, and the binding avidity of DCP-OVM-sIgE (DCP-OVM-sIgE/IC
) and DCP-OVM-sIgE/sIgG4 were compared between the negative and positive groups (
< 0.01). Among them, the variable with the greatest area under the receiver operating characteristic curve was DCP-OVM-sIgE/IC
(0.84), followed by DCP-OVM-sIgE/sIgG4 (0.81). DCP-OVM-sIgE/IC
and DCP-OVM-sIgE/sIgG4 are potentially useful markers for the prediction of positive OFCs during HE-SS-OIT and may allow proper evaluation of the current allergic status in the healing process during HE-SS-OIT.</description><subject>Allergens</subject><subject>Allergies</subject><subject>Animals</subject><subject>Asthma</subject><subject>Avidity</subject><subject>Binding</subject><subject>Biomarkers</subject><subject>Chickens</subject><subject>Children</subject><subject>Drug dosages</subject><subject>Egg Hypersensitivity - therapy</subject><subject>Eggs</subject><subject>Female</subject><subject>Food allergies</subject><subject>Food allergy</subject><subject>hen’s egg allergy</subject><subject>IgE binding avidity</subject><subject>Immunoglobulin E</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulins</subject><subject>Immunotherapy</subject><subject>Informed consent</subject><subject>oral food challenge</subject><subject>oral immunotherapy</subject><subject>Ovomucin</subject><subject>ovomucoid-specific IgE</subject><subject>ovomucoid-specific IgG4</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Protein arrays</subject><subject>Supervision</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkt9r2zAQx83YWEvXl_0BQ7CHjUE62bIl-2mkoT8ChRTSPRtZOjsXbCmT5YT8uftPJjdd045JDxJ3n_venXRR9DGmF4wV9LsZ4ixOEiHom-g0oSKZcJ6yty_uJ9F536_puAQVnL2PTphgIuMiPo1-P6yAzGxXoZEerSG2JpdoNJqGTLeo0e9H02Jru0FZ1JPlBhTWqMi8uSJT47Gyek-k0eSF5yY9umbSkHsHGpUn97ZHj1sgi8Er20H_qO1kS66t1WS2km0Lpgl2PbixhKWHzQ57IMvW7g7kvOsGY_0KnNzsCZoQha12YMgO_YrcgvnSk6smlB-0XLP_EL2rZdvD-dN5Fv28vnqY3U7uFjfz2fRuotKi8JNciSIrVB7XVVXlRcqrgjMmqNYpz3nCK0jzRPBMAa1TLlgNVIuqAikzyjnE7CyaH3S1lety47CTbl9aieWjwbqmlM6jaqEMYaxijPLwa2kcMtWcpkmeZ6ALqYQMWj8OWpuh6kArMD60_kr0tcfgqmzstowpownNx2q-Pik4-2uA3pcd9graVhqwQ18m-Zg-jUUe0M__oGs7OBPeKlBJkacZ4_RINTJ0gKa2IbEaRcupyPI0oQVNAnXxHypsDR0qa6DGYH8V8O0QoJztewf1c5MxLccBL48DHuBPL5_lGf07zuwPl9P2ZA</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Taniuchi, Shoichiro</creator><creator>Sakai, Rika</creator><creator>Nishida, Takahiro</creator><creator>Goma, Meguru</creator><creator>Mitomori, Masatoshi</creator><creator>Imaide, Aya</creator><creator>Enomoto, Masahiro</creator><creator>Nishino, Masamitsu</creator><creator>Okizuka, Yo</creator><creator>Kido, Hiroshi</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0009-0005-0397-7559</orcidid><orcidid>https://orcid.org/0000-0002-6369-3428</orcidid></search><sort><creationdate>20230601</creationdate><title>The Combination of Binding Avidity of Ovomucoid-Specific IgE Antibody and Specific IgG4 Antibody Can Predict Positive Outcomes of Oral Food Challenges during Stepwise Slow Oral Immunotherapy in Children with Hen's Egg Allergy</title><author>Taniuchi, Shoichiro ; 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Sixty-three children with HE allergy undergoing SS-OIT were subjected to repeated OFCs with HE. We measured the ovomucoid (OVM)-sIgE by ImmunoCAP or densely carboxylated protein (DCP) microarray, sIgG4 by DCP microarray, and the binding avidity of OVM-sIgE defined as the level of 1/IC
(nM) measured by competitive binding inhibition assays. The OFC was positive in 37 (59%) patients undergoing SS-OIT. Significant differences in DCP-OVM-sIgE, CAP-OVM-sIgE, I/IC
, DCP-OVM-sIgG4, the multiplication products of DCP-OVM-sIgE, and the binding avidity of DCP-OVM-sIgE (DCP-OVM-sIgE/IC
) and DCP-OVM-sIgE/sIgG4 were compared between the negative and positive groups (
< 0.01). Among them, the variable with the greatest area under the receiver operating characteristic curve was DCP-OVM-sIgE/IC
(0.84), followed by DCP-OVM-sIgE/sIgG4 (0.81). DCP-OVM-sIgE/IC
and DCP-OVM-sIgE/sIgG4 are potentially useful markers for the prediction of positive OFCs during HE-SS-OIT and may allow proper evaluation of the current allergic status in the healing process during HE-SS-OIT.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37375671</pmid><doi>10.3390/nu15122770</doi><orcidid>https://orcid.org/0009-0005-0397-7559</orcidid><orcidid>https://orcid.org/0000-0002-6369-3428</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Allergens Allergies Animals Asthma Avidity Binding Biomarkers Chickens Children Drug dosages Egg Hypersensitivity - therapy Eggs Female Food allergies Food allergy hen’s egg allergy IgE binding avidity Immunoglobulin E Immunoglobulin G Immunoglobulins Immunotherapy Informed consent oral food challenge oral immunotherapy Ovomucin ovomucoid-specific IgE ovomucoid-specific IgG4 Patients Prognosis Protein arrays Supervision |
title | The Combination of Binding Avidity of Ovomucoid-Specific IgE Antibody and Specific IgG4 Antibody Can Predict Positive Outcomes of Oral Food Challenges during Stepwise Slow Oral Immunotherapy in Children with Hen's Egg Allergy |
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