Prognostic value of stromal and epithelial periostin expression in human prostate cancer: correlation with clinical pathological features and the risk of biochemical relapse or death

The purpose of the present study was to evaluate the prognostic value of POSTN expression following prostatectomy. Periostin (POSTN) expression in prostate cancer (PCa) and in normal specimens was evaluated in 90 patients by an immuno-reactive score(IRS) based on the intensity of immunostaining and...

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Bibliographic Details
Published in:BMC cancer 2012-12, Vol.12 (1), p.625-625, Article 625
Main Authors: Nuzzo, Pier Vitale, Rubagotti, Alessandra, Zinoli, Linda, Ricci, Francesco, Salvi, Sandra, Boccardo, Simona, Boccardo, Francesco
Format: Article
Language:English
Subjects:
Aged
Biomarkers
Cell Adhesion Molecules - metabolism
Epithelium - metabolism
Extracellular matrix
Extracellular matrix proteins
Grants
Hospitals
Human
Humans
Immunohistochemistry
Male
Medical research
Middle Aged
Multivariate Analysis
Neoplasm Proteins - metabolism
Pathology
Patients
Physiological aspects
POSTN protein
Predictive Value of Tests
Prognosis
Prostate cancer
Prostatic neoplasms
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - surgery
Proteins
Statistical analysis
Stromal Cells - metabolism
Studies
Survival Analysis
Tumor proteins
Tumors
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Summary:The purpose of the present study was to evaluate the prognostic value of POSTN expression following prostatectomy. Periostin (POSTN) expression in prostate cancer (PCa) and in normal specimens was evaluated in 90 patients by an immuno-reactive score(IRS) based on the intensity of immunostaining and on the quantity of stained cells. The t-test was applied to compare IRS values in cancer specimens to values in normal specimens. Pearson's test was used to correlate POSTN expression to clinical pathologic features. PSA progression-free and survival curves were constructed by the Kaplan-Meier method and compared using the log-rank test. Multi-parametric models were constructed according to the Cox technique adding all the covariates predicting for either PSA progression or death into the models after univariate analysis. Both stromal and epithelial POSTN expression were significantly increased in tumor tissues. In particular, we found stromal expression to be significantly higher than epithelial expression as compared to normal tissues (p
ISSN:1471-2407
1471-2407
DOI:10.1186/1471-2407-12-625