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Anticoagulant rodenticide poisoning in calves - case report
ABSTRACT The aim was to report two cases of accidental Brodifacum poisoning in calves on a dairy farm. The animals presented a variable clinical picture of bleeding disorders with melena, epistaxis, orthopneic position, severe dyspnea, productive cough, coarse lung crackles, and expiratory groans. T...
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| Published in: | Arquivo brasileiro de medicina veterinária e zootecnia 2024, Vol.76 (6) |
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| container_title | Arquivo brasileiro de medicina veterinária e zootecnia |
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| creator | Almeida, R.A.T. Schunk, Y. S. Moraes, T. M. A. Moreira Júnior, C. A. Alves, S. R. Boeloni, J. N. Almeida, M. T. C. Rego, R.O. |
| description | ABSTRACT The aim was to report two cases of accidental Brodifacum poisoning in calves on a dairy farm. The animals presented a variable clinical picture of bleeding disorders with melena, epistaxis, orthopneic position, severe dyspnea, productive cough, coarse lung crackles, and expiratory groans. The male died, the female was euthanized, and both were sent for necropsy. The anatomopathological findings revealed a predominantly bleeding diathesis in the animals. During the investigation, blood serum, liver and kidney samples were collected for toxicologic measurement, which revealed concentrations of coumarin derivatives < 0.100µg/kg in all samples. The combination of history, clinical-pathologic findings, and toxicologic results confirmed the diagnosis.
RESUMO Objetivou-se relatar dois casos de intoxicação acidental por Brodifacum, em bezerros de uma fazenda de leite. Os animais apresentavam um quadro clínico variável de distúrbios hemorrágicos com melena, epistaxe, posição ortopneica, dispneia intensa, tosse produtiva, crepitação pulmonar grossa e gemidos expiratórios. O macho morreu, a fêmea foi submetida à eutanásia, e ambos foram encaminhados para exame necroscópico. Os achados anatomopatológicos revelaram, principalmente, um quadro de diátese hemorrágica nos animais. Durante o exame, foram coletadas amostras de soro sanguíneo, fígado e rins, para realização de dosagem toxicológica, obtendo-se como resultado concentrações de derivados de cumarina de |
| doi_str_mv | 10.1590/1678-4162-13234 |
| format | article |
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RESUMO Objetivou-se relatar dois casos de intoxicação acidental por Brodifacum, em bezerros de uma fazenda de leite. Os animais apresentavam um quadro clínico variável de distúrbios hemorrágicos com melena, epistaxe, posição ortopneica, dispneia intensa, tosse produtiva, crepitação pulmonar grossa e gemidos expiratórios. O macho morreu, a fêmea foi submetida à eutanásia, e ambos foram encaminhados para exame necroscópico. Os achados anatomopatológicos revelaram, principalmente, um quadro de diátese hemorrágica nos animais. Durante o exame, foram coletadas amostras de soro sanguíneo, fígado e rins, para realização de dosagem toxicológica, obtendo-se como resultado concentrações de derivados de cumarina de <0,100µg/kg em todas as amostras. Ao se associarem o histórico, os achados clinicopatológicos e o exame toxicológico, pode-se confirmar o diagnóstico.</description><identifier>ISSN: 0102-0935</identifier><identifier>ISSN: 1678-4162</identifier><identifier>EISSN: 1678-4162</identifier><identifier>DOI: 10.1590/1678-4162-13234</identifier><language>eng</language><publisher>Universidade Federal de Minas Gerais, Escola de Veterinária</publisher><subject>brodifacum ; coagulopathies ; poisoning ; rodenticides ; ruminants ; VETERINARY SCIENCES</subject><ispartof>Arquivo brasileiro de medicina veterinária e zootecnia, 2024, Vol.76 (6)</ispartof><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c271t-46144b05b4e5e1ab6ca9f7c78e03e3870e7d30092de4894c31ae7900d01f8b3e3</cites><orcidid>0009-0004-3324-6493 ; 0000-0002-1785-0066 ; 0009-0008-2684-5518 ; 0000-0003-0049-6854 ; 0009-0001-1259-7997 ; 0000-0001-8730-0425 ; 0000-0001-9291-7219 ; 0000-0002-9615-5263</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,24150,27924,27925</link.rule.ids></links><search><creatorcontrib>Almeida, R.A.T.</creatorcontrib><creatorcontrib>Schunk, Y. S.</creatorcontrib><creatorcontrib>Moraes, T. M. A.</creatorcontrib><creatorcontrib>Moreira Júnior, C. A.</creatorcontrib><creatorcontrib>Alves, S. R.</creatorcontrib><creatorcontrib>Boeloni, J. N.</creatorcontrib><creatorcontrib>Almeida, M. T. C.</creatorcontrib><creatorcontrib>Rego, R.O.</creatorcontrib><title>Anticoagulant rodenticide poisoning in calves - case report</title><title>Arquivo brasileiro de medicina veterinária e zootecnia</title><addtitle>Arq. Bras. Med. Vet. Zootec</addtitle><description>ABSTRACT The aim was to report two cases of accidental Brodifacum poisoning in calves on a dairy farm. The animals presented a variable clinical picture of bleeding disorders with melena, epistaxis, orthopneic position, severe dyspnea, productive cough, coarse lung crackles, and expiratory groans. The male died, the female was euthanized, and both were sent for necropsy. The anatomopathological findings revealed a predominantly bleeding diathesis in the animals. During the investigation, blood serum, liver and kidney samples were collected for toxicologic measurement, which revealed concentrations of coumarin derivatives < 0.100µg/kg in all samples. The combination of history, clinical-pathologic findings, and toxicologic results confirmed the diagnosis.
RESUMO Objetivou-se relatar dois casos de intoxicação acidental por Brodifacum, em bezerros de uma fazenda de leite. Os animais apresentavam um quadro clínico variável de distúrbios hemorrágicos com melena, epistaxe, posição ortopneica, dispneia intensa, tosse produtiva, crepitação pulmonar grossa e gemidos expiratórios. O macho morreu, a fêmea foi submetida à eutanásia, e ambos foram encaminhados para exame necroscópico. Os achados anatomopatológicos revelaram, principalmente, um quadro de diátese hemorrágica nos animais. Durante o exame, foram coletadas amostras de soro sanguíneo, fígado e rins, para realização de dosagem toxicológica, obtendo-se como resultado concentrações de derivados de cumarina de <0,100µg/kg em todas as amostras. Ao se associarem o histórico, os achados clinicopatológicos e o exame toxicológico, pode-se confirmar o diagnóstico.</description><subject>brodifacum</subject><subject>coagulopathies</subject><subject>poisoning</subject><subject>rodenticides</subject><subject>ruminants</subject><subject>VETERINARY SCIENCES</subject><issn>0102-0935</issn><issn>1678-4162</issn><issn>1678-4162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNo9kMtqwzAQRUVpoWnadbf-ASejhy2LrkLoIxDoou1a6DEOCq4VJKfQv6-dlKxmuMwcLoeQRwoLWilY0lo2paA1KylnXFyR2SW5JjOgwEpQvLoldznvAZhQis7I06ofgotmd-xMPxQpepyC4LE4xJBjH_pdEfrCme4Hc1GOS8Yi4SGm4Z7ctKbL-PA_5-Tr5flz_VZu318369W2dEzSoRQ1FcJCZQVWSI2tnVGtdLJB4MgbCSg9B1DMo2iUcJwalArAA20bO57MyebM9dHs9SGFb5N-dTRBn4KYdtqksXSH2lpsbGV9xSshGAUzwltwQiouvcJ6ZC3OrOwCdlHv4zH1Y3n9MRnSkyE2ugGAGigHMT4szw8uxZwTtpcCFPQkXk-a9aRZn8TzP7G_ccQ</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Almeida, R.A.T.</creator><creator>Schunk, Y. 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C.</creator><creator>Rego, R.O.</creator><general>Universidade Federal de Minas Gerais, Escola de Veterinária</general><general>Universidade Federal de Minas Gerais</general><scope>AAYXX</scope><scope>CITATION</scope><scope>GPN</scope><scope>DOA</scope><orcidid>https://orcid.org/0009-0004-3324-6493</orcidid><orcidid>https://orcid.org/0000-0002-1785-0066</orcidid><orcidid>https://orcid.org/0009-0008-2684-5518</orcidid><orcidid>https://orcid.org/0000-0003-0049-6854</orcidid><orcidid>https://orcid.org/0009-0001-1259-7997</orcidid><orcidid>https://orcid.org/0000-0001-8730-0425</orcidid><orcidid>https://orcid.org/0000-0001-9291-7219</orcidid><orcidid>https://orcid.org/0000-0002-9615-5263</orcidid></search><sort><creationdate>202401</creationdate><title>Anticoagulant rodenticide poisoning in calves - case report</title><author>Almeida, R.A.T. ; Schunk, Y. S. ; Moraes, T. M. A. ; Moreira Júnior, C. A. ; Alves, S. R. ; Boeloni, J. N. ; Almeida, M. T. C. ; Rego, R.O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c271t-46144b05b4e5e1ab6ca9f7c78e03e3870e7d30092de4894c31ae7900d01f8b3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>brodifacum</topic><topic>coagulopathies</topic><topic>poisoning</topic><topic>rodenticides</topic><topic>ruminants</topic><topic>VETERINARY SCIENCES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Almeida, R.A.T.</creatorcontrib><creatorcontrib>Schunk, Y. S.</creatorcontrib><creatorcontrib>Moraes, T. M. A.</creatorcontrib><creatorcontrib>Moreira Júnior, C. A.</creatorcontrib><creatorcontrib>Alves, S. R.</creatorcontrib><creatorcontrib>Boeloni, J. N.</creatorcontrib><creatorcontrib>Almeida, M. T. 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Zootec</addtitle><date>2024-01</date><risdate>2024</risdate><volume>76</volume><issue>6</issue><issn>0102-0935</issn><issn>1678-4162</issn><eissn>1678-4162</eissn><abstract>ABSTRACT The aim was to report two cases of accidental Brodifacum poisoning in calves on a dairy farm. The animals presented a variable clinical picture of bleeding disorders with melena, epistaxis, orthopneic position, severe dyspnea, productive cough, coarse lung crackles, and expiratory groans. The male died, the female was euthanized, and both were sent for necropsy. The anatomopathological findings revealed a predominantly bleeding diathesis in the animals. During the investigation, blood serum, liver and kidney samples were collected for toxicologic measurement, which revealed concentrations of coumarin derivatives < 0.100µg/kg in all samples. The combination of history, clinical-pathologic findings, and toxicologic results confirmed the diagnosis.
RESUMO Objetivou-se relatar dois casos de intoxicação acidental por Brodifacum, em bezerros de uma fazenda de leite. Os animais apresentavam um quadro clínico variável de distúrbios hemorrágicos com melena, epistaxe, posição ortopneica, dispneia intensa, tosse produtiva, crepitação pulmonar grossa e gemidos expiratórios. O macho morreu, a fêmea foi submetida à eutanásia, e ambos foram encaminhados para exame necroscópico. Os achados anatomopatológicos revelaram, principalmente, um quadro de diátese hemorrágica nos animais. Durante o exame, foram coletadas amostras de soro sanguíneo, fígado e rins, para realização de dosagem toxicológica, obtendo-se como resultado concentrações de derivados de cumarina de <0,100µg/kg em todas as amostras. Ao se associarem o histórico, os achados clinicopatológicos e o exame toxicológico, pode-se confirmar o diagnóstico.</abstract><pub>Universidade Federal de Minas Gerais, Escola de Veterinária</pub><doi>10.1590/1678-4162-13234</doi><orcidid>https://orcid.org/0009-0004-3324-6493</orcidid><orcidid>https://orcid.org/0000-0002-1785-0066</orcidid><orcidid>https://orcid.org/0009-0008-2684-5518</orcidid><orcidid>https://orcid.org/0000-0003-0049-6854</orcidid><orcidid>https://orcid.org/0009-0001-1259-7997</orcidid><orcidid>https://orcid.org/0000-0001-8730-0425</orcidid><orcidid>https://orcid.org/0000-0001-9291-7219</orcidid><orcidid>https://orcid.org/0000-0002-9615-5263</orcidid><oa>free_for_read</oa></addata></record> |
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| source | SciELO Brazil |
| subjects | brodifacum coagulopathies poisoning rodenticides ruminants VETERINARY SCIENCES |
| title | Anticoagulant rodenticide poisoning in calves - case report |
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