Gamma-Glutamyl Transferase: A Friend against Cholestatic Itch? A Retrospective Observational Data Analysis in Patients with Extrahepatic Cholestasis

Background and Aim of This Study. Itch frequently occurs in patients with chronic cholestasis. However, it remains unclear why some patients do and others do not develop pruritus. In addition, drug treatment is frequently ineffective. We repeatedly observed that cholestatic patients without itch had...

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Bibliographic Details
Published in:International journal of hepatology (New York) 2023-02, Vol.2023, p.2903171-7
Main Authors: Haijer, Floris W., Van Vliet, Cornelis B., Brusse-Keizer, Marjolein G. J., Van der Palen, Job A. M., Kerbert-Dreteler, Marjo J., Kolkman, Jeroen J.
Format: Article
Language:English
Subjects:
Acids
Bile
Bilirubin
Biomarkers
Cancer therapies
Care and treatment
Cholangiocarcinoma
Cholestasis
Comparative analysis
Data analysis
Endoscopy
Gallbladder diseases
Hepatitis
Hospitals
Jaundice, Obstructive
Kidney diseases
Laboratories
Liver diseases
Medical research
Medicine, Experimental
Pancreatic cancer
Patients
Proteins
Pruritus
Regression analysis
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Summary:Background and Aim of This Study. Itch frequently occurs in patients with chronic cholestasis. However, it remains unclear why some patients do and others do not develop pruritus. In addition, drug treatment is frequently ineffective. We repeatedly observed that cholestatic patients without itch had a relatively high serum gamma-glutamyl transpeptidase (GGT), relative to their serum bilirubin. The aim of this study was to validate this clinical observation. Methods. We included 235 patients with chronic extrahepatic cholestasis due to pancreatic cancer, cholangiocarcinoma, or papillary carcinoma. Results. GGT was significantly higher in patients without pruritus (median 967, IQR 587–1571) compared to patients with pruritus (median 561 IQR 266–1084 IU/l) (p
ISSN:2090-3448
2090-3456
DOI:10.1155/2023/2903171