Herpes Virus Amplicon Vectors

Since its emergence onto the gene therapy scene nearly 25 years ago, the replication-defective Herpes Simplex Virus Type-1 (HSV-1) amplicon has gained significance as a versatile gene transfer platform due to its extensive transgene capacity, widespread cellular tropism, minimal immunogenicity, and...

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Bibliographic Details
Published in:Viruses 2009-12, Vol.1 (3), p.594-629
Main Authors: de Silva, Suresh, Bowers, William J
Format: Article
Language:English
Subjects:
gene transfer
herpes simplex virus
HSV amplicon
immunotherapy
integration
Review
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Summary:Since its emergence onto the gene therapy scene nearly 25 years ago, the replication-defective Herpes Simplex Virus Type-1 (HSV-1) amplicon has gained significance as a versatile gene transfer platform due to its extensive transgene capacity, widespread cellular tropism, minimal immunogenicity, and its amenability to genetic manipulation. Herein, we detail the recent advances made with respect to the design of the HSV amplicon, its numerous in vitro and in vivo applications, and the current impediments this virus-based gene transfer platform faces as it navigates a challenging path towards future clinical testing.
ISSN:1999-4915
1999-4915
DOI:10.3390/v1030594