Comprehensive Analysis of Clinical Trials Registration for Lupus Nephritis Therapy on ClinicalTrials.gov

Objective: Clinical trials are the most effective method for evaluating therapeutic strategies. The purpose of this study was to comprehensively assess the characteristics of trials on lupus nephritis (LN) and provide a reference for LN treatment and research. Methods: Registered therapeutic trials...

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Bibliographic Details
Published in:Frontiers in medicine 2021-06, Vol.8, p.680302-680302
Main Authors: Gao, Yanfang, Wang, Yuhan, Li, Rongshan, Zhou, Xiaoshuang
Format: Article
Language:English
Subjects:
biologics
ClinicalTrials.gov
drug control
lupus nephritis
Medicine
trial registration
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Summary:Objective: Clinical trials are the most effective method for evaluating therapeutic strategies. The purpose of this study was to comprehensively assess the characteristics of trials on lupus nephritis (LN) and provide a reference for LN treatment and research. Methods: Registered therapeutic trials on drug interventions for LN were obtained from ClinicalTrials.gov up to December 3, 2020. The general characteristics, methodological characteristics, detailed characteristics, investigated drugs, eligibility criteria, and outcome measures of these trials were analyzed. Results: A total of 126 eligible trials were evaluated, and these trials mainly investigated the initial treatment of adult proliferative LN. Half of the trials enrolled
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2021.680302