Association between Serum Vitamin C and the Blood Pressure: A Systematic Review and Meta-Analysis of Observational Studies

Background. Hypertension is regarded as a major and independent risk factor of cardiovascular diseases, and numerous studies observed an inverse correlation between vitamin C intake and blood pressure. Aim. Our aim is to investigate the relationship between serum vitamin C and blood pressure, includ...

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Bibliographic Details
Published in:Cardiovascular therapeutics 2020, Vol.2020 (2020), p.1-11
Main Authors: Bu, Huaien, Takagi, Ken, Mizuno, Kaito, Wang, Hongwu, Tan, Xiaodong, Zhao, Wenli, Ran, Li, Zhao, Ye
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aged, 80 and over
Analysis
Ascorbic Acid - blood
Biomarkers - blood
Blood Pressure
Cardiovascular disease
Diet therapy
Female
Humans
Hypertension
Hypertension - diagnosis
Hypertension - epidemiology
Hypertension - physiopathology
Male
Medical research
Medicine, Experimental
Meta-analysis
Middle Aged
Observational studies
Observational Studies as Topic
Quality
Researchers
Risk Assessment
Risk Factors
Software
Statistical analysis
Studies
Vitamin C
Vitamin D Deficiency - blood
Vitamin D Deficiency - diagnosis
Vitamin D Deficiency - epidemiology
Young Adult
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Summary:Background. Hypertension is regarded as a major and independent risk factor of cardiovascular diseases, and numerous studies observed an inverse correlation between vitamin C intake and blood pressure. Aim. Our aim is to investigate the relationship between serum vitamin C and blood pressure, including the concentration differences and the correlation strength. Method. Two independent researchers searched and screened articles from the National Library of Medicine, Cochrane Library, Web of Science, China National Knowledge Infrastructure, VIP databases, and WANFANG databases. A total of 18 eligible studies were analyzed in the Reviewer Manager 5.3 software, including 14 English articles and 4 Chinese articles. Results. In the evaluation of serum vitamin C levels, the concentration in hypertensive subjects is 15.13 μmol/L lower than the normotensive ones (mean difference=−15.13, 95% CI [-24.19, -6.06], and P=0.001). Serum vitamin C has a significant inverse relation with both systolic blood pressure (Fisher’s Z=−0.17, 95% CI [-0.20, -0.15], P
ISSN:1755-5914
1755-5922
DOI:10.1155/2020/4940673