Role of APD-Ribosylation in Bone Health and Disease

The transfer of adenosine diphosphate (ADP)-ribose unit(s) from nicotinamide adenine dinucleotide (NAD ) to acceptor proteins is known as ADP-ribosylation. This post-translational modification (PTM) unavoidably alters protein functions and signaling networks, thereby impacting cell behaviors and tis...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2019-10, Vol.8 (10), p.1201
Main Authors: Wang, Chun, Mbalaviele, Gabriel
Format: Article
Language:English
Subjects:
Adenine
Adenosine
Adenosine diphosphate
Adipocytes
ADP-ribosylation
artds
Arthritis
bone
Bone marrow
Bone remodeling
Disease
Enzymes
Homeostasis
Kinases
NAD
osteoblasts
osteoclasts
Post-translation
Proteins
Review
Ribose
Ribosylation
Smooth muscle
Stem cells
Transcription factors
Tumor necrosis factor-TNF
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Summary:The transfer of adenosine diphosphate (ADP)-ribose unit(s) from nicotinamide adenine dinucleotide (NAD ) to acceptor proteins is known as ADP-ribosylation. This post-translational modification (PTM) unavoidably alters protein functions and signaling networks, thereby impacting cell behaviors and tissue outcomes. As a ubiquitous mechanism, ADP-ribosylation affects multiple tissues, including bones, as abnormal ADP-ribosylation compromises bone development and remodeling. In this review, we describe the effects of ADP-ribosylation in bone development and maintenance, and highlight the underlying mechanisms.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells8101201