The Induction Mechanism of Ferroptosis, Necroptosis, and Pyroptosis in Inflammatory Bowel Disease, Colorectal Cancer, and Intestinal Injury

Cell death includes programmed and nonprogrammed cell death. The former mainly includes ferroptosis, necroptosis, pyroptosis, autophagy, and apoptosis, while the latter refers to necrosis. Accumulating evidence shows that ferroptosis, necroptosis, and pyroptosis play essential regulatory roles in th...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2023-05, Vol.13 (5), p.820
Main Authors: Zhou, Ping, Zhang, Shun, Wang, Maohua, Zhou, Jun
Format: Article
Language:English
Subjects:
Antioxidants
Apoptosis
Autophagy
Biosynthesis
Care and treatment
Cell death
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - genetics
Development and progression
Fatty acids
Ferroptosis
Health aspects
Homeostasis
Humans
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory Bowel Diseases - genetics
intestinal injury
Intestine
Iron
Ischemia
Kinases
Lipid peroxidation
Lipids
Membranes
Metabolism
Metabolites
Mitochondria
Molecular modelling
Necroptosis
Permeability
Phosphorylation
Proteins
Pyroptosis
Reperfusion
Review
Sepsis
Sulfur
Therapeutic applications
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Summary:Cell death includes programmed and nonprogrammed cell death. The former mainly includes ferroptosis, necroptosis, pyroptosis, autophagy, and apoptosis, while the latter refers to necrosis. Accumulating evidence shows that ferroptosis, necroptosis, and pyroptosis play essential regulatory roles in the development of intestinal diseases. In recent years, the incidence of inflammatory bowel disease (IBD), colorectal cancer (CRC), and intestinal injury induced by intestinal ischemia-reperfusion (I/R), sepsis, and radiation have gradually increased, posing a significant threat to human health. The advancement in targeted therapies for intestinal diseases based on ferroptosis, necroptosis, and pyroptosis provides new strategies for treating intestinal diseases. Herein, we review ferroptosis, necroptosis, and pyroptosis with respect to intestinal disease regulation and highlight the underlying molecular mechanisms for potential therapeutic applications.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom13050820