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Efficacy and safety of fecal microbiota transplantation in the treatment of ulcerative colitis: a systematic review and meta-analysis
To explore the efficacy and safety of fecal microbiota transplantation (FMT) as a treatment approach for ulcerative colitis (UC), a comprehensive systematic review and meta-analysis of randomized controlled trials was conducted. To collect and evaluate randomized controlled trials of high quality on...
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| Published in: | Scientific reports 2023-09, Vol.13 (1), p.14494-14494, Article 14494 |
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| creator | Feng, Jing Chen, Yexin Liu, Yan Lin, Lin Lin, Xiujuan Gong, Wenxiu Xia, Rongmu He, Jianquan Sheng, Jianwen Cai, Huimei Xiao, Chuanxing |
| description | To explore the efficacy and safety of fecal microbiota transplantation (FMT) as a treatment approach for ulcerative colitis (UC), a comprehensive systematic review and meta-analysis of randomized controlled trials was conducted. To collect and evaluate randomized controlled trials of high quality on FMT for UC, we searched a number of databases, including PubMed, Web of Science, Cochrane, Embase, and Medline, for studies published between the establishment of the databases and March 2023. We conducted a meta-analysis of the studies using Review Manager software (version 5.4.1) to determine the differences in rates of remission and adverse reactions between the FMT group and the control group, utilizing the risk ratio (
RR
) and 95% confidence interval (
CI
) to combine our findings. A total of 13 randomized controlled trials (RCTs) on the efficacy of FMT in patients with UC were included in the study, in which 580 patients participated, including 293 patients treated with FMT and 287 control subjects. Meta-analysis revealed that clinical remission was significantly better in the FMT group than in the control group [
RR
= 1.73; 95%
CI
= (1.41, 2.12);
P
|
| doi_str_mv | 10.1038/s41598-023-41182-6 |
| format | article |
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RR
) and 95% confidence interval (
CI
) to combine our findings. A total of 13 randomized controlled trials (RCTs) on the efficacy of FMT in patients with UC were included in the study, in which 580 patients participated, including 293 patients treated with FMT and 287 control subjects. Meta-analysis revealed that clinical remission was significantly better in the FMT group than in the control group [
RR
= 1.73; 95%
CI
= (1.41, 2.12);
P
< 0.00001]; endoscopic remission was significantly better in the FMT group than in the control group [
RR
= 1.74; 95%
CI
= (1.24, 2.44);
P
= 0.001]. Additionally, there were no significant differences in the incidence of adverse reactions between the two groups [
RR
= 1.00; 95%
CI
= (0.86, 1.15);
P
= 0.96]. Fecal microbiota transplantation has shown potential as a therapeutic intervention for inducing clinical remission in ulcerative colitis UC; nevertheless, the attainment of endoscopic remission and the maintenance of long-term remission continue to present challenges. Safety concerns persist throughout the treatment process, necessitating the implementation of measures to augment both safety and success rates.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-023-41182-6</identifier><identifier>PMID: 37661203</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/326 ; 692/4020 ; Clinical trials ; Endoscopy ; Fecal microflora ; Feces ; Humanities and Social Sciences ; Inflammatory bowel disease ; Meta-analysis ; Microbiota ; multidisciplinary ; Patients ; Remission ; Remission (Medicine) ; Safety ; Science ; Science (multidisciplinary) ; Side effects ; Systematic review ; Transplantation ; Ulcerative colitis</subject><ispartof>Scientific reports, 2023-09, Vol.13 (1), p.14494-14494, Article 14494</ispartof><rights>The Author(s) 2023</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Springer Nature Limited 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-3a8627affd5e9c0e0bb6353a7747aacfd98a1afd5c5ec8c115631b77741117953</citedby><cites>FETCH-LOGICAL-c518t-3a8627affd5e9c0e0bb6353a7747aacfd98a1afd5c5ec8c115631b77741117953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2860210857/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2860210857?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids></links><search><creatorcontrib>Feng, Jing</creatorcontrib><creatorcontrib>Chen, Yexin</creatorcontrib><creatorcontrib>Liu, Yan</creatorcontrib><creatorcontrib>Lin, Lin</creatorcontrib><creatorcontrib>Lin, Xiujuan</creatorcontrib><creatorcontrib>Gong, Wenxiu</creatorcontrib><creatorcontrib>Xia, Rongmu</creatorcontrib><creatorcontrib>He, Jianquan</creatorcontrib><creatorcontrib>Sheng, Jianwen</creatorcontrib><creatorcontrib>Cai, Huimei</creatorcontrib><creatorcontrib>Xiao, Chuanxing</creatorcontrib><title>Efficacy and safety of fecal microbiota transplantation in the treatment of ulcerative colitis: a systematic review and meta-analysis</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><description>To explore the efficacy and safety of fecal microbiota transplantation (FMT) as a treatment approach for ulcerative colitis (UC), a comprehensive systematic review and meta-analysis of randomized controlled trials was conducted. To collect and evaluate randomized controlled trials of high quality on FMT for UC, we searched a number of databases, including PubMed, Web of Science, Cochrane, Embase, and Medline, for studies published between the establishment of the databases and March 2023. We conducted a meta-analysis of the studies using Review Manager software (version 5.4.1) to determine the differences in rates of remission and adverse reactions between the FMT group and the control group, utilizing the risk ratio (
RR
) and 95% confidence interval (
CI
) to combine our findings. A total of 13 randomized controlled trials (RCTs) on the efficacy of FMT in patients with UC were included in the study, in which 580 patients participated, including 293 patients treated with FMT and 287 control subjects. Meta-analysis revealed that clinical remission was significantly better in the FMT group than in the control group [
RR
= 1.73; 95%
CI
= (1.41, 2.12);
P
< 0.00001]; endoscopic remission was significantly better in the FMT group than in the control group [
RR
= 1.74; 95%
CI
= (1.24, 2.44);
P
= 0.001]. Additionally, there were no significant differences in the incidence of adverse reactions between the two groups [
RR
= 1.00; 95%
CI
= (0.86, 1.15);
P
= 0.96]. Fecal microbiota transplantation has shown potential as a therapeutic intervention for inducing clinical remission in ulcerative colitis UC; nevertheless, the attainment of endoscopic remission and the maintenance of long-term remission continue to present challenges. Safety concerns persist throughout the treatment process, necessitating the implementation of measures to augment both safety and success rates.</description><subject>631/326</subject><subject>692/4020</subject><subject>Clinical trials</subject><subject>Endoscopy</subject><subject>Fecal microflora</subject><subject>Feces</subject><subject>Humanities and Social Sciences</subject><subject>Inflammatory bowel disease</subject><subject>Meta-analysis</subject><subject>Microbiota</subject><subject>multidisciplinary</subject><subject>Patients</subject><subject>Remission</subject><subject>Remission (Medicine)</subject><subject>Safety</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Side effects</subject><subject>Systematic review</subject><subject>Transplantation</subject><subject>Ulcerative colitis</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9Us2KFDEQbkRxl3FfwFPAi5fWVNLpdHsRWVZdWPCi51Cdqcxm6O6MSWZkHsD3NjO9qOvBQEj4_lJUqqpeAn8DXHZvUwOq72ouZN0AdKJun1SXgjeqFlKIp3_dL6qrlLa8LCX6Bvrn1YXUbQuCy8vq541z3qI9MpzXLKGjfGTBMUcWRzZ5G8PgQ0aWI85pN-KcMfswMz-zfE8FJswTzflk2o-WYqEPxGwYffbpHUOWjinTVGDLIh08_Tg_NVHGGmccj8mnF9Uzh2Oiq4dzVX37ePP1-nN99-XT7fWHu9oq6HItsWuFRufWinrLiQ9DK5VErRuNaN267xCwsFaR7SyAaiUMutAAoHslV9XtkrsOuDW76CeMRxPQmzMQ4sZgLIWOZAarrOsEt4OmxlmOLUitbUE1cAJZst4vWbv9MNHalh5EHB-FPmZmf2824WCAN1o1JW5VvX5IiOH7nlI2k0-WxtJkCvtkRNfyFk67SF_9I92GfSzdW1QCeKd0UYlFVX4tpUjudzXAzWlqzDI1pkyNOU-NaYtJLqZUxPOG4p_o_7h-ATZTxg8</recordid><startdate>20230903</startdate><enddate>20230903</enddate><creator>Feng, Jing</creator><creator>Chen, Yexin</creator><creator>Liu, Yan</creator><creator>Lin, Lin</creator><creator>Lin, Xiujuan</creator><creator>Gong, Wenxiu</creator><creator>Xia, Rongmu</creator><creator>He, Jianquan</creator><creator>Sheng, Jianwen</creator><creator>Cai, Huimei</creator><creator>Xiao, Chuanxing</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Nature Portfolio</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20230903</creationdate><title>Efficacy and safety of fecal microbiota transplantation in the treatment of ulcerative colitis: a systematic review and meta-analysis</title><author>Feng, Jing ; 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To collect and evaluate randomized controlled trials of high quality on FMT for UC, we searched a number of databases, including PubMed, Web of Science, Cochrane, Embase, and Medline, for studies published between the establishment of the databases and March 2023. We conducted a meta-analysis of the studies using Review Manager software (version 5.4.1) to determine the differences in rates of remission and adverse reactions between the FMT group and the control group, utilizing the risk ratio (
RR
) and 95% confidence interval (
CI
) to combine our findings. A total of 13 randomized controlled trials (RCTs) on the efficacy of FMT in patients with UC were included in the study, in which 580 patients participated, including 293 patients treated with FMT and 287 control subjects. Meta-analysis revealed that clinical remission was significantly better in the FMT group than in the control group [
RR
= 1.73; 95%
CI
= (1.41, 2.12);
P
< 0.00001]; endoscopic remission was significantly better in the FMT group than in the control group [
RR
= 1.74; 95%
CI
= (1.24, 2.44);
P
= 0.001]. Additionally, there were no significant differences in the incidence of adverse reactions between the two groups [
RR
= 1.00; 95%
CI
= (0.86, 1.15);
P
= 0.96]. Fecal microbiota transplantation has shown potential as a therapeutic intervention for inducing clinical remission in ulcerative colitis UC; nevertheless, the attainment of endoscopic remission and the maintenance of long-term remission continue to present challenges. Safety concerns persist throughout the treatment process, necessitating the implementation of measures to augment both safety and success rates.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>37661203</pmid><doi>10.1038/s41598-023-41182-6</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/326 692/4020 Clinical trials Endoscopy Fecal microflora Feces Humanities and Social Sciences Inflammatory bowel disease Meta-analysis Microbiota multidisciplinary Patients Remission Remission (Medicine) Safety Science Science (multidisciplinary) Side effects Systematic review Transplantation Ulcerative colitis |
| title | Efficacy and safety of fecal microbiota transplantation in the treatment of ulcerative colitis: a systematic review and meta-analysis |
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