In vivo bone regeneration by differently designed titanium membrane with or without surface treatment: a study in rat calvarial defects

The current objective was to evaluate six groups of titanium membranes in a rat calvarial defect model, regarding the surface treatment with or without calcium-phosphate coating and surface topography with no, small, or large holes. Critical size defects (Ф = 8 mm, n = 42) were surgically created in...

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Bibliographic Details
Published in:Journal of tissue engineering 2019-01, Vol.10, p.2041731419831466-2041731419831466
Main Authors: Jang, Yong-Seok, Moon, So-Hee, Nguyen, Thuy-Duong Thi, Lee, Min-Ho, Oh, Tae-Ju, Han, A-Lum, Bae, Tae-Sung
Format: Article
Language:English
Subjects:
Alizarin
Bone growth
Bone mineral density
Calcein
Calcium
Calcium phosphates
Calvaria
Computed tomography
Connective tissues
Defects
Functional Biomaterials and Extracellular Matrices for Dental Tissue Repair and Regeneration
Histology
Membranes
Osteogenesis
Phosphate coatings
Phosphates
Regeneration
Regeneration (physiology)
Surface treatment
Surgical implants
Titanium
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Summary:The current objective was to evaluate six groups of titanium membranes in a rat calvarial defect model, regarding the surface treatment with or without calcium-phosphate coating and surface topography with no, small, or large holes. Critical size defects (Ф = 8 mm, n = 42) were surgically created in rat calvaria, and then were treated by one of the six groups. Biopsies were obtained at 4 weeks (n = 5 per group) for micro-computed tomography and histomorphometric analyses. Fluorochrome bone markers were injected in two rats each group at 1 (Alizarin red), 3 (Calcein green) and 5 weeks (Oxytetracyclin yellow), followed by histological examination at 7 weeks to assess bone regeneration dynamic. At 4 weeks, the highest bone volume was observed in no-hole groups independent of surface treatment (p 
ISSN:2041-7314
2041-7314
DOI:10.1177/2041731419831466