Tracking research trends and hotspots in sperm DNA fragmentation testing for the evaluation of male infertility: a scientometric analysis

• Published in: Reproductive biology and endocrinology 2019-12, Vol.17 (1), p.110-110, Article 110
• Main Authors: Baskaran, Saradha, Agarwal, Ashok, Panner Selvam, Manesh Kumar, Finelli, Renata, Robert, Kathy Amy, Iovine, Concetta, Pushparaj, Peter Natesan, Samanta, Luna, Harlev, Avi, Henkel, Ralf
• Format: Article
• Language: English
• Subjects: Analysis; Anopheles; Asthenozoospermia - genetics; Author productivity; Bibliographic data bases; Biomedical Research - trends; Deoxyribonucleic acid; Diagnosis; DNA; DNA Damage; DNA Fragmentation; DNA nucleotidylexotransferase; Genomes; Humans; In Situ Nick-End Labeling; Infertility; Infertility, male; Infertility, Male - genetics; Keywords; Male; Male infertility; Medical diagnosis; Medical prognosis; National Institutes of Health (U.S.); Oxidative stress; Pregnancy; Prognosis; Publishing - trends; Reproduction; Reproductive Techniques, Assisted; Researchers; Scientometric analysis; Scientometrics; Software; Sperm; Spermatozoa - chemistry; Statistical analysis; Studies; Trends; United States; Varicocele; Varicocele - genetics
• ISSN: 1477-7827; 1477-7827
• DOI: 10.1186/s12958-019-0550-3

This article describes the research trends in sperm DNA fragmentation (SDF) over the past 20 years (1999-2018) using a scientometric approach. A stepwise approach was adopted to retrieve scientometric data (articles per year, authors, affiliations, journals, countries) from Scopus and analyze the publication pattern of SDF with reference to key areas of research in the field of Andrology. A total of 2121 articles were retrieved related to SDF. Our data revealed an increasing research trend in SDF (n = 33 to n = 173) over the past 20 years (R  = 0.894). Most productive country in publications was the USA (n = 450), while Agarwal A. (n = 129) being the most productive author. Most of the articles in SDF were primarily focused on lifestyle (n = 157), asthenozoospermia (n = 135) and varicocele (130). Mechanistic studies on SDF were published twice as much as prognostic/diagnostic studies, with significant emphasis on oxidative stress. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) was the most widely used technique to evaluate SDF. Publications on SDF related to assisted reproductive techniques also showed a linear increasing trend (R  = 0.933). Our analysis revealed an increasing trend in SDF publications predominantly investigating lifestyle, asthenozoospermia and varicocele conditions with TUNEL being the most widely used technique. A substantial increase in research is warranted to establish SDF as prognostic/diagnostic parameter to evaluate clinical scenarios and ART outcomes.