Current understanding of Alzheimer's disease diagnosis and treatment [version 1; peer review: 2 approved]

Alzheimer's disease is the most common cause of dementia worldwide, with the prevalence continuing to grow in part because of the aging world population. This neurodegenerative disease process is characterized classically by two hallmark pathologies: β-amyloid plaque deposition and neurofibrill...

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Bibliographic Details
Published in:F1000 research 2018, Vol.7, p.1161
Main Authors: Weller, Jason, Budson, Andrew
Format: Article
Language:English
Subjects:
Accuracy
Activities of daily living
Aging
Alzheimer's disease
Biomarkers
Blood tests
Clinical trials
Cognition & reasoning
Cognitive ability
Dementia
Dementia disorders
Diagnosis
FDA approval
Fluids
Medical imaging
Memory
Mental disorders
Neural networks
Neurofibrillary tangles
Neuroimaging
Pathology
Patients
Proteins
Researchers
Review
Tau protein
β-Amyloid
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Summary:Alzheimer's disease is the most common cause of dementia worldwide, with the prevalence continuing to grow in part because of the aging world population. This neurodegenerative disease process is characterized classically by two hallmark pathologies: β-amyloid plaque deposition and neurofibrillary tangles of hyperphosphorylated tau. Diagnosis is based upon clinical presentation fulfilling several criteria as well as fluid and imaging biomarkers. Treatment is currently targeted toward symptomatic therapy, although trials are underway that aim to reduce the production and overall burden of pathology within the brain. Here, we discuss recent advances in our understanding of the clinical evaluation and treatment of Alzheimer's disease, with updates regarding clinical trials still in progress.
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.14506.1