Combined effect of high-dose vitamin A, vitamin E supplementation, and zinc on adult patients with diabetes: A randomized trial

• Published in: Journal of advanced research 2021-02, Vol.28, p.27-33
• Main Authors: Said, Eman, Mousa, Shrook, Fawzi, May, Sabry, Nirmeen A., Farid, Samar
• Format: Article
• Language: English
• Subjects: Insulin; Type 2 diabetes mellitus; Vitamin A; Vitamin E; Zinc
• ISSN: 2090-1232; 2090-1224
• DOI: 10.1016/j.jare.2020.06.013

[Display omitted] In type 2 diabetes mellitus (T2DM), hyperglycemia leads to oxidative insult. Vitamins A and E have antioxidant potentials and may help in managing diabetes. The combined effect of high-dose vitamin A plus E supplementation with and without zinc on T2DM, has never been examined. This study aimed to evaluate and compare the effect of high-dose vitamin A plus E supplementation (AE) versus high-dose vitamin A plus E with zinc (AEZ), on different diabetic parameters. Ninety-eight patients with T2DM were randomized to receive either: 50,000 IU vitamin A and 100 mg vitamin E (AE group, N=36), an equivalent dose of vitamin A and E combined with 25 mg zinc (AEZ group, N=35), or no supplements (control group, N=27) for three months. Compared to the control, the AEZ group showed significant reductions in fasting blood glucose, 2 hours postprandial blood glucose, and glycated hemoglobin (HbA1c) with significant increases in homeostasis model assessment of beta-cell function and difference value of fasting insulin. Two hair loss cases were recorded in both treated groups. Although vitamin A needs dose moderation, these results suggest that, high-dose vitamin A plus E supplementation combined with zinc may improve glycemic control, β-cell function, and insulin secretion in adults with T2DM.