Quantification of left atrial function in patients with non-obstructive hypertrophic cardiomyopathy by cardiovascular magnetic resonance feature tracking imaging: a feasibility and reproducibility study

• Published in: Journal of cardiovascular magnetic resonance 2020-01, Vol.22 (1), p.1-1, Article 1
• Main Authors: Yang, Yingxia, Yin, Gang, Jiang, Yong, Song, Lei, Zhao, Shihua, Lu, Minjie
• Format: Article
• Language: English
• Subjects: Adult; Aged; Arrhythmia; Atrial Fibrillation - etiology; Atrial Fibrillation - physiopathology; Atrial Function, Left; Cardiac arrhythmia; Cardiomyopathy; Cardiomyopathy, Hypertrophic - complications; Cardiomyopathy, Hypertrophic - diagnostic imaging; Cardiomyopathy, Hypertrophic - physiopathology; Cardiovascular disease; Cardiovascular magnetic resonance; Care and treatment; Case-Control Studies; Comparative analysis; Diameters; Electrocardiography; Enlargement; Feasibility Studies; Feature tracking; Female; Fibrillation; Heart; Heart Atria - diagnostic imaging; Heart Atria - physiopathology; Humans; Hypertrophic cardiomyopathy; Left atrial dysfunction; Magnetic resonance; Magnetic resonance imaging; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Myocardial diseases; Observer Variation; Parameters; Patients; Predictive Value of Tests; Reproducibility; Reproducibility of Results; Reservoirs (Water); Resonance; Risk Factors; Strain analysis; Strain rate; Stroke Volume; Ventricle; Ventricular Function, Left; Young Adult
• ISSN: 1097-6647; 1532-429X
• DOI: 10.1186/s12968-019-0589-5

Atrial fibrillation (AF) is the most common arrhythmia in hypertrophic cardiomyopathy (HCM) and is associated with adverse outcomes in HCM patients. Although the left atrial (LA) diameter has consistently been identified as a strong predictor of AF in HCM patients, the relationship between LA dysfunction and AF still remains unclear. The aim of this study is to evaluate the LA function in patients with non-obstructive HCM (NOHCM) utilizing cardiovascular magnetic resonance feature tracking (CMR-FT). Thirty-three patients with NOHCM and 28 healthy controls were studied. The global and regional LA function and left ventricular (LV) function were compared between the two groups. The following LA global functional parameters were quantitively analyzed: reservoir function (total ejection fraction [LA total EF], total strain [ε ], peak positive strain rate [SRs]), conduit function (passive ejection fraction [LA passive EF], passive strain [ε ], peak early-negative SR [SRe]), and booster pump function (active ejection fraction [LA active EF], active strain [ε ], peak late-negative SR [SRa]). The LA wall was automatically divided into 6 segments: anterior, antero-roof, inferior, septal, septal-roof and lateral. Three LA strain parameters (ε , ε , ε ) and their corresponding strain rate parameters (SRs, SRe, SRa) during the reservoir, conduit and booster pump LA phases were segmentally measured and analyzed. The LA reservoir (LA total EF: 57.6 ± 8.2% vs. 63.9 ± 6.4%, p