Non-Coding RNAs: Novel Regulators of Macrophage Homeostasis in Ocular Vascular Diseases

Ocular neovascularization can impair vision and threaten patients' quality of life. However, the underlying mechanism is far from transparent. In all mammals, macrophages are a population of cells playing pivotal roles in the innate immune system and the first line of defense against pathogens....

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2024-03, Vol.14 (3), p.328
Main Authors: Zhang, Qiuyang, Liu, Qing, Feng, Siguo, Li, Xiumiao, Jiang, Qin
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Apoptosis
Blood circulation disorders
Bone marrow
Chromatin
Enzymes
Eye diseases
Gene expression
Genetic aspects
Health aspects
Homeostasis
Homeostasis - genetics
Humans
Immune system
Innate immunity
Lipids
macrophage
Macrophages
Mammals
MicroRNAs
Non-coding RNA
pathological angiogenesis
Physiological aspects
Proteins
Quality of Life
Review
RNA
RNA, Long Noncoding
RNA, Untranslated - genetics
Vascular diseases
Vascular Diseases - genetics
Vascularization
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Summary:Ocular neovascularization can impair vision and threaten patients' quality of life. However, the underlying mechanism is far from transparent. In all mammals, macrophages are a population of cells playing pivotal roles in the innate immune system and the first line of defense against pathogens. Therefore, it has been speculated that the disfunction of macrophage homeostasis is involved in the development of ocular vascular diseases. Moreover, various studies have found that non-coding RNAs (ncRNAs) regulate macrophage homeostasis. This study reviewed past studies of the regulatory roles of ncRNAs in macrophage homeostasis in ocular vascular diseases.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom14030328