Measured GFR by Utilizing Population Pharmacokinetic Methods to Determine Iohexol Clearance

There is an increasing demand for accurately measured glomerular filtration rate (GFR). Iohexol serum clearance has become a new gold standard, but it is challenging when GFR is low and 24-hour sampling is required for accurate results. The primary aim of this study was to develop an iohexol pharmac...

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Bibliographic Details
Published in:Kidney international reports 2020-02, Vol.5 (2), p.189-198
Main Authors: Åsberg, Anders, Bjerre, Anna, Almaas, Runar, Luis-Lima, Sergio, Robertsen, Ida, Salvador, Cathrin Lytomt, Porrini, Esteban, Schwartz, George J., Hartmann, Anders, Bergan, Stein
Format: Article
Language:English
Subjects:
Clinical Research
iohexol clearance
kidney
measured GFR
pharmacokinetics
population model
renal
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Summary:There is an increasing demand for accurately measured glomerular filtration rate (GFR). Iohexol serum clearance has become a new gold standard, but it is challenging when GFR is low and 24-hour sampling is required for accurate results. The primary aim of this study was to develop an iohexol pharmacokinetic population model for accurate determination of individual GFR using limited sampling for up to 5 hours also when renal function is 
ISSN:2468-0249
2468-0249
DOI:10.1016/j.ekir.2019.11.012