Deciphering and targeting host factors to counteract SARS-CoV-2 and coronavirus infections: insights from CRISPR approaches

Severe respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses depend on host factors for the process of viral infection and replication. A better understanding of the dynamic interplay between viral pathogens and host cells, as well as identifying of virus-host dependencies, offers...

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Bibliographic Details
Published in:Frontiers in genome editing 2023-07, Vol.5, p.1231656-1231656
Main Authors: Cui, Zhifen, Wang, Hongyan, Dong, Yizhou, Liu, Shan-Lu, Wang, Qianben
Format: Article
Language:English
Subjects:
coronavirus infections
CRISPR/Cas13-based gene therapy
CRISPR/Cas9-based screening
Genome Editing
host factors
SARS-CoV-2
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Summary:Severe respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses depend on host factors for the process of viral infection and replication. A better understanding of the dynamic interplay between viral pathogens and host cells, as well as identifying of virus-host dependencies, offers valuable insights into disease mechanisms and informs the development of effective therapeutic strategies against viral infections. This review delves into the key host factors that facilitate or hinder SARS-CoV-2 infection and replication, as identified by CRISPR/Cas9-based screening platforms. Furthermore, we explore CRISPR/Cas13-based gene therapy strategies aimed at targeting these host factors to inhibit viral infection, with the ultimate goal of eradicating SARS-CoV-2 and preventing and treating related coronaviruses for future outbreaks.
ISSN:2673-3439
2673-3439
DOI:10.3389/fgeed.2023.1231656