Genomic, transcriptomic, and phenotypic differences among archetype Shigella flexneri strains of serotypes 2a, 3a, and 6

Given the genomic diversity between serotypes and the paucity of data to support serotype-specific phenotypic differences, we applied and functional analyses of archetype strains of 2457T ( 2a), J17B ( 3a), and CH060 ( 6). These archetype strains represent the three leading serotypes recommended for...

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Bibliographic Details
Published in:mSphere 2023-12, Vol.8 (6), p.e0040823-e0040823
Main Authors: Gabor, Caitlin E, Hazen, Tracy H, Delaine-Elias, BreOnna C, Rasko, David A, Barry, Eileen M
Format: Article
Language:English
Subjects:
Antigens
Antimicrobial agents
Bile
Chromosomes
comparative genomics
Diarrhea
E coli
Gene Expression Profiling
Genomes
Genomics
Genomics and Proteomics
Host-pathogen interactions
Pathogens
Phenotypic variations
Phylogenetics
Plasmids
Proteins
Research Article
Serogroup
Serotypes
Shigella
Shigella flexneri
Shigella flexneri - genetics
Shigellosis
Transcriptomics
Vaccines
Vaccines, Combined
Virulence
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Summary:Given the genomic diversity between serotypes and the paucity of data to support serotype-specific phenotypic differences, we applied and functional analyses of archetype strains of 2457T ( 2a), J17B ( 3a), and CH060 ( 6). These archetype strains represent the three leading serotypes recommended for inclusion in multivalent vaccines. Characterizing the genomic and phenotypic variation among these clinically prevalent serotypes is an important step toward understanding serotype-specific host-pathogen interactions to optimize the efficacy of multivalent vaccines and therapeutics. This study underpins the importance for further large-scale serotype-targeted analyses.
ISSN:2379-5042
2379-5042
DOI:10.1128/msphere.00408-23