Lymphomatoid Granulomatosis with Splenomegaly and Pancytopenia

Lymphomatoid granulomatosis （LG） is an angiocentric lymphoproliferative disease. It usually involves lung, skin, and central nervous system, but splenomegaly and pancytopenia are the rare manifestations of the disease. We report a 15-year-old boy presented with fever, dry cough and dyspnea from two...

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Bibliographic Details
Published in:Zhongguo fei ai za zhi 2010, Vol.13 (1), p.84-86
Main Author: Abolhasan HALVANI Mohammad Bagher OWLIA Ramin SAMI
Format: Article
Language:Chinese
Subjects:
Lymphomatoid granulomatosis
Pancytopenia
Splenomegaly
临床分析
全血细胞减少症
淋巴瘤
肉芽肿病
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Summary:Lymphomatoid granulomatosis （LG） is an angiocentric lymphoproliferative disease. It usually involves lung, skin, and central nervous system, but splenomegaly and pancytopenia are the rare manifestations of the disease. We report a 15-year-old boy presented with fever, dry cough and dyspnea from two months ago, after admission patient had nodular lesions on the left leg and hepatosplenomegaly. Then he manifested neurologic signs such as seizure, aphasia and right-sided hemiplegia. Chest X-ray and CT scan revealed bilateral pulmonary nodules predominantly in lower lobes and peripheral lung fields. Laboratory exams showed panc）rtopenia. Skin biopsy was done, and histopathological examination and irnmunohistochemistry evaluation confirmed lymphomatoid granulomatosis. He was treated with steroid and cydophosphamide but succumbed by neurologic involvement.
ISSN:1009-3419
1999-6187
DOI:10.3779/j.issn.1009-3419.2010.01.17