Pathophysiology of high fat diet induced obesity: impact of probiotic banana juice on obesity associated complications and hepatosteatosis

The high fat diet alters intestinal microbiota due to increased intestinal permeability and susceptibility to microbial antigens leads to metabolic endotoxemia. But probiotic juices reported for various health benefits. In this background we hypothesized that pectinase treated probiotic banana juice...

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Bibliographic Details
Published in:Scientific reports 2020-10, Vol.10 (1), p.16894-17, Article 16894
Main Authors: Konda, Prabhakar Yellanur, Poondla, Vijayakumar, Jaiswal, Krishna Kumar, Dasari, Sreenivasulu, Uyyala, Reddemma, Surtineni, Venkata Prasad, Egi, Janardhan Yadav, Masilamani, Anthony Johnson Antony, Bestha, Lakshmi, Konanki, Sreenath, Muthulingam, Muthukumaran, Lingamgunta, Lakshman Kumar, Aloor, Bindu Prasuna, Tirumalaraju, Sridevi, Sade, Ankanna, Ratnam Kamsala, Venkata, Nagaraja, Sreeharsha, Ramakrishnan, Ranjani, Natesan, Vijayakumar
Format: Article
Language:English
Subjects:
631/1647
631/326
631/45
631/61
Animals
Antioxidants - metabolism
Body Weight - drug effects
Diet, High-Fat - adverse effects
Fatty Liver - drug therapy
Fatty Liver - metabolism
Fruit and Vegetable Juices
Humanities and Social Sciences
Insulin Resistance - physiology
Lipid Metabolism - drug effects
Lipid Peroxidation - drug effects
Lipids
Liver - drug effects
Liver - metabolism
Male
multidisciplinary
Musa - metabolism
Non-alcoholic Fatty Liver Disease - drug therapy
Non-alcoholic Fatty Liver Disease - metabolism
Obesity - drug therapy
Obesity - metabolism
Oxidative Stress - drug effects
Probiotics - pharmacology
Rats
Rats, Wistar
Saccharomyces cerevisiae - drug effects
Science
Science (multidisciplinary)
Triglycerides - metabolism
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Summary:The high fat diet alters intestinal microbiota due to increased intestinal permeability and susceptibility to microbial antigens leads to metabolic endotoxemia. But probiotic juices reported for various health benefits. In this background we hypothesized that pectinase treated probiotic banana juice has diverse effects on HFD induced obesity and non-alcoholic steatohepatitis. 20 weeks fed HFD successfully induced obesity and its associated complications in experimental rats. The supplementation of probiotic banana juice for 5 months at a dose of 5 mL/kg bw/day resulted significant decrease ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-73670-4