Neuron‐inducing therapy using embryonic neural progenitor cells embedding positively charged gold nanoparticles in rats with complete spinal cord injury

Dear Editor, Traumatic spinal cord injury (SCI) results in neuron loss and axon degeneration at the injury area.1 Embryonic-spinal-cord-derived neural progenitor cells (NPCs) have been highlighted given that NPCs can differentiate into neurons.2 However, under SCI most NPCs undergo differentiation i...

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Bibliographic Details
Published in:Clinical and translational medicine 2022-07, Vol.12 (7), p.e981-n/a
Main Authors: Han, Gong H., Ko, Wan‐Kyu, Kim, Seong J., Lee, Daye, Jeong, Dabin, Han, Inbo, Sheen, Seung H., Sohn, Seil
Format: Article
Language:English
Subjects:
Letter to the Editor
Nanoparticles
Neurons
Spinal cord injuries
Stem cells
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Summary:Dear Editor, Traumatic spinal cord injury (SCI) results in neuron loss and axon degeneration at the injury area.1 Embryonic-spinal-cord-derived neural progenitor cells (NPCs) have been highlighted given that NPCs can differentiate into neurons.2 However, under SCI most NPCs undergo differentiation into astrocytes rather than into neurons.3 Glial fibrillary acidic protein (GFAP) barriers from activated astrocytes following SCI disrupt the recovery of damaged neurons/axons in injured areas.4 We aimed to improve injured neurons using NPCs embedding positively charged gold nanoparticles (GNPs) in complete SCI rats. The NPCs embedding pGNPs induced the recovery of injured neurons in SCI rats (Figure 3G). The NPCs embedding pGNPs also induced the recovery of motor function after SCI in rats (Figure 3P). [...]we suggest that the transplantation of pGNP-embedded NPCs derived from the embryonic spinal cord can be effective therapy for the repair of SCI.
ISSN:2001-1326
2001-1326
DOI:10.1002/ctm2.981