Immunization with heterologous flaviviruses protective against fatal West Nile encephalitis

Prior immunization of hamsters with three heterologous flaviviruses (Japanese encephalitis virus [JEV] SA14-2-8 vaccine, wild-type St. Louis encephalitis virus [SLEV], and Yellow fever virus [YFV] 17D vaccine) reduces the severity of subsequent West Nile virus (WNV) infection. Groups of adult hamste...

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Bibliographic Details
Published in:Emerging infectious diseases 2002-03, Vol.8 (3), p.245-251
Main Authors: Tesh, Robert B, Travassos da Rosa, Amelia P A, Guzman, Hilda, Araujo, Tais P, Xiao, Shu-Yuan
Format: Article
Language:English
Subjects:
Animals
Antibodies, Viral - blood
Antibody Formation
arboviruses
Communicable diseases
Cricetinae
Encephalitis
Encephalitis Virus, Japanese - immunology
Encephalitis Virus, St. Louis - immunology
experimental infection
Flavivirus
Flavivirus - immunology
Hamsters
immune response
Immunization
Japanese encephalitis virus
Physiological aspects
Prevention
Vaccines
Viruses
West Nile fever
West Nile Fever - immunology
West Nile virus - immunology
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Summary:Prior immunization of hamsters with three heterologous flaviviruses (Japanese encephalitis virus [JEV] SA14-2-8 vaccine, wild-type St. Louis encephalitis virus [SLEV], and Yellow fever virus [YFV] 17D vaccine) reduces the severity of subsequent West Nile virus (WNV) infection. Groups of adult hamsters were immunized with each of the heterologous flaviviruses; approximately 30 days later, the animals were injected intraperitoneally with a virulent New York strain of WNV. Subsequent levels of viremia, antibody response, and deaths were compared with those in nonimmune (control) hamsters. Immunity to JEV and SLEV was protective against clinical encephalitis and death after challenge with WNV. The antibody response in the sequentially infected hamsters also illustrates the difficulty in making a serologic diagnosis of WNV infection in animals (or humans) with preexisting Flavivirus immunity.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid0803.010238