Application of Gene Editing Technology in Resistance Breeding of Livestock

As a new genetic engineering technology, gene editing can precisely modify the specific gene sequence of the organism’s genome. In the last 10 years, with the rapid development of gene editing technology, zinc-finger nucleases (ZFNs), transcription activator-like endonucleases (TALENs), and CRISPR/C...

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Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2022-07, Vol.12 (7), p.1070
Main Authors: Wang, Sutian, Qu, Zixiao, Huang, Qiuyan, Zhang, Jianfeng, Lin, Sen, Yang, Yecheng, Meng, Fanming, Li, Jianhao, Zhang, Kunli
Format: Article
Language:English
Subjects:
Amino acids
Animal diseases
Animal husbandry
Animals
Binding sites
Breeding
cattle
CRISPR
Disease
Disease resistance
Efficiency
Fibroblasts
Gene expression
Genetic engineering
Genetic modification
Genome editing
genome engineering
Genomes
Health care
Hogs
Infections
Livestock
Livestock breeding
Microorganisms
Mutation
Nuclease
Nucleotide sequence
Pathogens
pigs
Proteins
Rabbits
Review
Sheep
Technology
Transcription factors
Zebrafish
Zinc finger proteins
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Summary:As a new genetic engineering technology, gene editing can precisely modify the specific gene sequence of the organism’s genome. In the last 10 years, with the rapid development of gene editing technology, zinc-finger nucleases (ZFNs), transcription activator-like endonucleases (TALENs), and CRISPR/Cas9 systems have been applied to modify endogenous genes in organisms accurately. Now, gene editing technology has been used in mice, zebrafish, pigs, cattle, goats, sheep, rabbits, monkeys, and other species. Breeding for disease-resistance in agricultural animals tends to be a difficult task for traditional breeding, but gene editing technology has made this easier. In this work, we overview the development and application of gene editing technology in the resistance breeding of livestock. Also, we further discuss the prospects and outlooks of gene editing technology in disease-resistance breeding.
ISSN:2075-1729
2075-1729
DOI:10.3390/life12071070