Warfarin doses for anticoagulation therapy in elderly patients with chronic atrial fibrillation

Anticoagulation is a challenge for the prophylaxis of thromboembolic events in elderly patients with chronic atrial fibrillation. Stable anticoagulation is defined as the time within >70% of the therapeutic range. However, the dosage required to achieve stable anticoagulation remains unknown. The...

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Bibliographic Details
Published in:Clinics (São Paulo, Brazil) Brazil), 2012-01, Vol.67 (6), p.543-546
Main Authors: de Padua Mansur, Antonio, Takada, Julio Yoshio, Avakian, Solange Desiree, Strunz, Celia M.C.
Format: Article
Language:English
Subjects:
Age Factors
Aged
Aged, 80 and over
Anticoagulants - administration & dosage
Anticoagulation
Atrial Fibrillation - blood
Chi-Square Distribution
Chronic Atrial Fibrillation
Chronic Disease
Clinical Science
Elderly
Female
Humans
International Normalized Ratio
Male
MEDICINE, GENERAL & INTERNAL
Reference Values
Time Factors
Treatment Outcome
Warfarin
Warfarin - administration & dosage
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Summary:Anticoagulation is a challenge for the prophylaxis of thromboembolic events in elderly patients with chronic atrial fibrillation. Stable anticoagulation is defined as the time within >70% of the therapeutic range. However, the dosage required to achieve stable anticoagulation remains unknown. The aim of this study was to analyze the warfarin dose necessary for the maintenance of stable oral anticoagulation therapy in elderly patients. We analyzed 112 consecutive outpatients with atrial fibrillation who were ≥65 years of age, had received anticoagulation therapy with warfarin for more than 1 year and had a stable international normalized ratio between 2.0 and 3.0 for ≥6 months. The international normalized ratio was measured in the central laboratory using the traditional method. The patients were stratified according to the following age groups:
ISSN:1807-5932
1980-5322
1980-5322
DOI:10.6061/clinics/2012(06)01