Evaluation of Cytotoxic and Antibacterial Effect of Methanolic Extract of Paeonia lactiflora

Background and objectives: Bacterial antibiotics have had several side effects. Therefore, interest in natural substances with less side effects is increasing these days. Paeonia lactiflora, the root of Paeonia lactiflora, is used as a raw material for medicines. In this study, we investigated the a...

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Bibliographic Details
Published in:Medicina (Kaunas, Lithuania) Lithuania), 2022-09, Vol.58 (9), p.1272
Main Authors: Choi, Yu-Ri, Kang, Min-Kyung
Format: Article
Language:English
Subjects:
anti-bacterial
Bacteria
Candida albicans
Cytotoxicity
Dental caries
Flavonoids
Paeonia lactiflora
Polyphenols
Scanning electron microscopy
Streptococcus infections
Streptococcus mutans
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Summary:Background and objectives: Bacterial antibiotics have had several side effects. Therefore, interest in natural substances with less side effects is increasing these days. Paeonia lactiflora, the root of Paeonia lactiflora, is used as a raw material for medicines. In this study, we investigated the antibacterial effect and the cytotoxicity of Paeonia lactiflora extract. Materials and Methods: For cytotoxicity, MTT analysis according to ISO 10993-5 was performed. The antibacterial test of the Paeonia lactiflora was determined from bacterial viability, Inhibition zone test, CFU (colony forming unit) and SEM (scanning electron microscope). To confirm the antibacterial component of Paeonia lactiflora, the content of flavonoids and polyphenols was analyzed. Results: Our results showed that Paeonia lactiflora extract contained flavonoids and polyphenols, which exhibited antimicrobial activity against Streptococcus mutans (S. mutans) and Candida albicans (C. ablicans). Further, the cytotoxicity of Paeonia lactiflora extract was low. Conclusions: We believe that our study makes a significant contribution to the literature because it demonstrates that Paeonia lactiflora extract can be used as an antibiotic.
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina58091272