Analysis of ageing-associated grey matter volume in patients with multiple sclerosis shows excess atrophy in subcortical regions

Age of onset in multiple sclerosis (MS) exerts an influence on the course of disease. This study examined whether global and regional brain volumes differed between "younger" and "older" onset MS subjects who were matched for short disease duration, mean 1.9 years and burden as m...

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Bibliographic Details
Published in:NeuroImage clinical 2017-01, Vol.13 (C), p.9-15
Main Authors: Bishop, Courtney A, Newbould, Rexford D, Lee, Jean Sz, Honeyfield, Lesley, Quest, Rebecca, Colasanti, Alessandro, Ali, Rehiana, Mattoscio, Miriam, Cortese, Antonio, Nicholas, Richard, Matthews, Paul M, Muraro, Paolo A, Waldman, Adam D
Format: Article
Language:English
Subjects:
Adult
Age Factors
Age of Onset
Aging - pathology
Amygdala - diagnostic imaging
Amygdala - pathology
Atrophy
Atrophy - pathology
Corpus Striatum - diagnostic imaging
Corpus Striatum - pathology
Gray Matter - diagnostic imaging
Gray Matter - pathology
Grey matter
Hippocampus - diagnostic imaging
Hippocampus - pathology
Humans
Image analysis
Magnetic Resonance Imaging
Male
Middle Aged
Multiple sclerosis
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - pathology
Regular
Thalamus - diagnostic imaging
Thalamus - pathology
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Summary:Age of onset in multiple sclerosis (MS) exerts an influence on the course of disease. This study examined whether global and regional brain volumes differed between "younger" and "older" onset MS subjects who were matched for short disease duration, mean 1.9 years and burden as measured by the MS Severity Score and relapses. 21 younger-onset MS subjects (age 30.4 ± 3.2 years) were compared with 17 older-onset (age 48.7 ± 3.3 years) as well as age-matched controls (  = 31, 31.9 ± 3.5 years and  = 21, 47.3 ± 4.0 years). All subjects underwent 3D volumetric T1 and T2-FLAIR imaging. White matter (WM) and grey matter (GM) lesions were outlined manually. Lesions were filled prior to tissue and structural segmentation to reduce classification errors. Volume loss versus control was predominantly in the subcortical GM, at > 13% loss. Younger and older-onset MS subjects had similar, strong excess loss in the putamen, thalamus, and nucleus accumbens. No excess loss was detected in the amygdala or pallidum. The hippocampus and caudate showed significant excess loss in the younger group (  
ISSN:2213-1582
2213-1582
DOI:10.1016/j.nicl.2016.11.005