Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression

Paeoniflorin (PF) is an active monoterpene glycoside extracted from Pall. PF has exhibited antitumor effects in various cancer types. However, the effects of PF in pancreatic cancer are largely unexplored. Here, we showed that PF suppressed growth of pancreatic cancer cell lines Capan-1 and MIAPaCa-...

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Bibliographic Details
Published in:Drug design, development and therapy development and therapy, 2017-01, Vol.11, p.2481-2491
Main Authors: Li, Yuejun, Gong, Lili, Qi, Ruili, Sun, Qian, Xia, Xinxin, He, Haihui, Ren, Jianshu, Zhu, Ouning, Zhuo, Debin
Format: Article
Language:English
Subjects:
Adult
Aged
Anticancer properties
Antitumor activity
Apoptosis
Apoptosis - drug effects
Bax protein
Cancer
Cancer cells
Cancer therapies
Care and treatment
Cell growth
Cell Line, Tumor
Cell proliferation
Cell Proliferation - drug effects
Chinese medicine
Cytotoxicity
Development and progression
Diagnosis
DNA microarrays
Ectopic expression
Female
Gene expression
Glucosides - isolation & purification
Glucosides - pharmacology
Growth
Health aspects
HTRA3
Humans
Irradiation
Lung cancer
Male
Microarray Analysis
Middle Aged
Monoterpenes - isolation & purification
Monoterpenes - pharmacology
Original Research
Ovarian cancer
Paeonia - chemistry
Paeoniflorin
Pancreatic cancer
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - pathology
Proteins
Serine Endopeptidases - genetics
Software
Traditional Chinese medicine
Tumor cell lines
Tumors
Up-Regulation - drug effects
X ray irradiation
Young Adult
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Summary:Paeoniflorin (PF) is an active monoterpene glycoside extracted from Pall. PF has exhibited antitumor effects in various cancer types. However, the effects of PF in pancreatic cancer are largely unexplored. Here, we showed that PF suppressed growth of pancreatic cancer cell lines Capan-1 and MIAPaCa-2 and profoundly sensitized these cells to X-ray irradiation. Through microarray analysis, we identified HTRA3, a tumor-suppressor candidate gene, as the most increased gene upon PF treatment in Capan-1 cells. Ectopic expression of HTRA3 led to reduced cell proliferation and increased expression of apoptotic protein Bax, suggesting a tumor suppressive role of HTRA3 in pancreatic cancer cells. Together, our results provide a set group of genetic proofs and biological proofs that PF inhibited pancreatic cancer growth by upregulating HTRA3.
ISSN:1177-8881
1177-8881
DOI:10.2147/DDDT.S134518