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Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression
Paeoniflorin (PF) is an active monoterpene glycoside extracted from Pall. PF has exhibited antitumor effects in various cancer types. However, the effects of PF in pancreatic cancer are largely unexplored. Here, we showed that PF suppressed growth of pancreatic cancer cell lines Capan-1 and MIAPaCa-...
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| Published in: | Drug design, development and therapy development and therapy, 2017-01, Vol.11, p.2481-2491 |
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| container_title | Drug design, development and therapy |
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| creator | Li, Yuejun Gong, Lili Qi, Ruili Sun, Qian Xia, Xinxin He, Haihui Ren, Jianshu Zhu, Ouning Zhuo, Debin |
| description | Paeoniflorin (PF) is an active monoterpene glycoside extracted from
Pall. PF has exhibited antitumor effects in various cancer types. However, the effects of PF in pancreatic cancer are largely unexplored. Here, we showed that PF suppressed growth of pancreatic cancer cell lines Capan-1 and MIAPaCa-2 and profoundly sensitized these cells to X-ray irradiation. Through microarray analysis, we identified HTRA3, a tumor-suppressor candidate gene, as the most increased gene upon PF treatment in Capan-1 cells. Ectopic expression of HTRA3 led to reduced cell proliferation and increased expression of apoptotic protein Bax, suggesting a tumor suppressive role of HTRA3 in pancreatic cancer cells. Together, our results provide a set group of genetic proofs and biological proofs that PF inhibited pancreatic cancer growth by upregulating HTRA3. |
| doi_str_mv | 10.2147/DDDT.S134518 |
| format | article |
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Pall. PF has exhibited antitumor effects in various cancer types. However, the effects of PF in pancreatic cancer are largely unexplored. Here, we showed that PF suppressed growth of pancreatic cancer cell lines Capan-1 and MIAPaCa-2 and profoundly sensitized these cells to X-ray irradiation. Through microarray analysis, we identified HTRA3, a tumor-suppressor candidate gene, as the most increased gene upon PF treatment in Capan-1 cells. Ectopic expression of HTRA3 led to reduced cell proliferation and increased expression of apoptotic protein Bax, suggesting a tumor suppressive role of HTRA3 in pancreatic cancer cells. Together, our results provide a set group of genetic proofs and biological proofs that PF inhibited pancreatic cancer growth by upregulating HTRA3.</description><identifier>ISSN: 1177-8881</identifier><identifier>EISSN: 1177-8881</identifier><identifier>DOI: 10.2147/DDDT.S134518</identifier><identifier>PMID: 28860718</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>Adult ; Aged ; Anticancer properties ; Antitumor activity ; Apoptosis ; Apoptosis - drug effects ; Bax protein ; Cancer ; Cancer cells ; Cancer therapies ; Care and treatment ; Cell growth ; Cell Line, Tumor ; Cell proliferation ; Cell Proliferation - drug effects ; Chinese medicine ; Cytotoxicity ; Development and progression ; Diagnosis ; DNA microarrays ; Ectopic expression ; Female ; Gene expression ; Glucosides - isolation & purification ; Glucosides - pharmacology ; Growth ; Health aspects ; HTRA3 ; Humans ; Irradiation ; Lung cancer ; Male ; Microarray Analysis ; Middle Aged ; Monoterpenes - isolation & purification ; Monoterpenes - pharmacology ; Original Research ; Ovarian cancer ; Paeonia - chemistry ; Paeoniflorin ; Pancreatic cancer ; Pancreatic Neoplasms - drug therapy ; Pancreatic Neoplasms - pathology ; Proteins ; Serine Endopeptidases - genetics ; Software ; Traditional Chinese medicine ; Tumor cell lines ; Tumors ; Up-Regulation - drug effects ; X ray irradiation ; Young Adult</subject><ispartof>Drug design, development and therapy, 2017-01, Vol.11, p.2481-2491</ispartof><rights>COPYRIGHT 2017 Dove Medical Press Limited</rights><rights>2017. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Li et al. This work is published and licensed by Dove Medical Press Limited 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c662t-d19519ebe29d6277f810c9a894287d5531552f1a9ab7214deb027f833821295d3</citedby><orcidid>0000-0002-4698-9905</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2226358900/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2226358900?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,25734,27905,27906,36993,36994,44571,53772,53774,74875</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28860718$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yuejun</creatorcontrib><creatorcontrib>Gong, Lili</creatorcontrib><creatorcontrib>Qi, Ruili</creatorcontrib><creatorcontrib>Sun, Qian</creatorcontrib><creatorcontrib>Xia, Xinxin</creatorcontrib><creatorcontrib>He, Haihui</creatorcontrib><creatorcontrib>Ren, Jianshu</creatorcontrib><creatorcontrib>Zhu, Ouning</creatorcontrib><creatorcontrib>Zhuo, Debin</creatorcontrib><title>Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression</title><title>Drug design, development and therapy</title><addtitle>Drug Des Devel Ther</addtitle><description>Paeoniflorin (PF) is an active monoterpene glycoside extracted from
Pall. PF has exhibited antitumor effects in various cancer types. However, the effects of PF in pancreatic cancer are largely unexplored. Here, we showed that PF suppressed growth of pancreatic cancer cell lines Capan-1 and MIAPaCa-2 and profoundly sensitized these cells to X-ray irradiation. Through microarray analysis, we identified HTRA3, a tumor-suppressor candidate gene, as the most increased gene upon PF treatment in Capan-1 cells. Ectopic expression of HTRA3 led to reduced cell proliferation and increased expression of apoptotic protein Bax, suggesting a tumor suppressive role of HTRA3 in pancreatic cancer cells. Together, our results provide a set group of genetic proofs and biological proofs that PF inhibited pancreatic cancer growth by upregulating HTRA3.</description><subject>Adult</subject><subject>Aged</subject><subject>Anticancer properties</subject><subject>Antitumor activity</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Bax protein</subject><subject>Cancer</subject><subject>Cancer cells</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Chinese medicine</subject><subject>Cytotoxicity</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>DNA microarrays</subject><subject>Ectopic expression</subject><subject>Female</subject><subject>Gene expression</subject><subject>Glucosides - isolation & purification</subject><subject>Glucosides - pharmacology</subject><subject>Growth</subject><subject>Health aspects</subject><subject>HTRA3</subject><subject>Humans</subject><subject>Irradiation</subject><subject>Lung cancer</subject><subject>Male</subject><subject>Microarray Analysis</subject><subject>Middle Aged</subject><subject>Monoterpenes - isolation & purification</subject><subject>Monoterpenes - pharmacology</subject><subject>Original Research</subject><subject>Ovarian cancer</subject><subject>Paeonia - chemistry</subject><subject>Paeoniflorin</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - drug therapy</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Proteins</subject><subject>Serine Endopeptidases - genetics</subject><subject>Software</subject><subject>Traditional Chinese medicine</subject><subject>Tumor cell lines</subject><subject>Tumors</subject><subject>Up-Regulation - drug effects</subject><subject>X ray irradiation</subject><subject>Young Adult</subject><issn>1177-8881</issn><issn>1177-8881</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkk2P0zAQhiMEYj_gxhlFQkJ7oCVjx18XpGoL7EorgaBwtRzHSV2ldtZOgP33ONuytAj54NH4mdee15NlL6CYIyjZ2-VyuZp_BVwS4I-yUwDGZpxzeHwQn2RnMW6KgmKKiqfZCeKcFgz4afb9szLe2abzwbo8jn0fTIwm5r1yOhg1WJ3rFJqQa9N1eRv8z2GdV3f5mMh27BLh2vxq9WWBc_Prvtp69yx70qgumuf7_Tz79uH96vJqdvPp4_Xl4mamKUXDrAZBQJjKIFFTxFjDodBCcVEizmpCMBCCGlBCVSw1W5uqQAnCmCNAgtT4PLve6dZebWQf7FaFO-mVlfcJH1qpQuqhM7KqgSiFSVMCKQEBxxyjitaMTw8AnbTe7bT6sdqaWhs3BNUdiR6fOLuWrf8hCWElETQJXOwFgr8dTRzk1sbJNeWMH6MEgSlQLARK6Kt_0I0fg0tWSYQQxYSLovhLtSo1YF3j0716EpWL5A3nJYMyUfP_UGnVZmu1d6axKX9U8PqgYG1UN6yj78YhfVw8Bt_sQB18jME0D2ZAIafhk9Pwyf3wJfzloYEP8J9pw78BMPHR2g</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Li, Yuejun</creator><creator>Gong, Lili</creator><creator>Qi, Ruili</creator><creator>Sun, Qian</creator><creator>Xia, Xinxin</creator><creator>He, Haihui</creator><creator>Ren, Jianshu</creator><creator>Zhu, Ouning</creator><creator>Zhuo, Debin</creator><general>Dove Medical Press Limited</general><general>Taylor & Francis Ltd</general><general>Dove Medical Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7XB</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>KB0</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4698-9905</orcidid></search><sort><creationdate>20170101</creationdate><title>Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression</title><author>Li, Yuejun ; Gong, Lili ; Qi, Ruili ; Sun, Qian ; Xia, Xinxin ; He, Haihui ; Ren, Jianshu ; Zhu, Ouning ; Zhuo, Debin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c662t-d19519ebe29d6277f810c9a894287d5531552f1a9ab7214deb027f833821295d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anticancer properties</topic><topic>Antitumor activity</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Bax protein</topic><topic>Cancer</topic><topic>Cancer cells</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>Chinese medicine</topic><topic>Cytotoxicity</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>DNA microarrays</topic><topic>Ectopic expression</topic><topic>Female</topic><topic>Gene expression</topic><topic>Glucosides - isolation & purification</topic><topic>Glucosides - pharmacology</topic><topic>Growth</topic><topic>Health aspects</topic><topic>HTRA3</topic><topic>Humans</topic><topic>Irradiation</topic><topic>Lung cancer</topic><topic>Male</topic><topic>Microarray Analysis</topic><topic>Middle Aged</topic><topic>Monoterpenes - isolation & purification</topic><topic>Monoterpenes - pharmacology</topic><topic>Original Research</topic><topic>Ovarian cancer</topic><topic>Paeonia - chemistry</topic><topic>Paeoniflorin</topic><topic>Pancreatic cancer</topic><topic>Pancreatic Neoplasms - drug therapy</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Proteins</topic><topic>Serine Endopeptidases - genetics</topic><topic>Software</topic><topic>Traditional Chinese medicine</topic><topic>Tumor cell lines</topic><topic>Tumors</topic><topic>Up-Regulation - drug effects</topic><topic>X ray irradiation</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yuejun</creatorcontrib><creatorcontrib>Gong, Lili</creatorcontrib><creatorcontrib>Qi, Ruili</creatorcontrib><creatorcontrib>Sun, Qian</creatorcontrib><creatorcontrib>Xia, Xinxin</creatorcontrib><creatorcontrib>He, Haihui</creatorcontrib><creatorcontrib>Ren, Jianshu</creatorcontrib><creatorcontrib>Zhu, Ouning</creatorcontrib><creatorcontrib>Zhuo, Debin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Drug design, development and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yuejun</au><au>Gong, Lili</au><au>Qi, Ruili</au><au>Sun, Qian</au><au>Xia, Xinxin</au><au>He, Haihui</au><au>Ren, Jianshu</au><au>Zhu, Ouning</au><au>Zhuo, Debin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression</atitle><jtitle>Drug design, development and therapy</jtitle><addtitle>Drug Des Devel Ther</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>11</volume><spage>2481</spage><epage>2491</epage><pages>2481-2491</pages><issn>1177-8881</issn><eissn>1177-8881</eissn><abstract>Paeoniflorin (PF) is an active monoterpene glycoside extracted from
Pall. PF has exhibited antitumor effects in various cancer types. However, the effects of PF in pancreatic cancer are largely unexplored. Here, we showed that PF suppressed growth of pancreatic cancer cell lines Capan-1 and MIAPaCa-2 and profoundly sensitized these cells to X-ray irradiation. Through microarray analysis, we identified HTRA3, a tumor-suppressor candidate gene, as the most increased gene upon PF treatment in Capan-1 cells. Ectopic expression of HTRA3 led to reduced cell proliferation and increased expression of apoptotic protein Bax, suggesting a tumor suppressive role of HTRA3 in pancreatic cancer cells. Together, our results provide a set group of genetic proofs and biological proofs that PF inhibited pancreatic cancer growth by upregulating HTRA3.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>28860718</pmid><doi>10.2147/DDDT.S134518</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4698-9905</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Anticancer properties Antitumor activity Apoptosis Apoptosis - drug effects Bax protein Cancer Cancer cells Cancer therapies Care and treatment Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Chinese medicine Cytotoxicity Development and progression Diagnosis DNA microarrays Ectopic expression Female Gene expression Glucosides - isolation & purification Glucosides - pharmacology Growth Health aspects HTRA3 Humans Irradiation Lung cancer Male Microarray Analysis Middle Aged Monoterpenes - isolation & purification Monoterpenes - pharmacology Original Research Ovarian cancer Paeonia - chemistry Paeoniflorin Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Proteins Serine Endopeptidases - genetics Software Traditional Chinese medicine Tumor cell lines Tumors Up-Regulation - drug effects X ray irradiation Young Adult |
| title | Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression |
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