Systematic Review and Meta-Analysis of Risk Factors Associated with Postoperative Stress Hyperglycemia in Patients without Diabetes Following Cardiac Surgery

• Published in: Reviews in cardiovascular medicine 2025-01, Vol.26 (1), p.25485
• Main Authors: Zhang, Mengli, Zhang, Ziyi, Zhu, Ningning, Wang, Lulu, Huang, Hui, Wang, Yike, Xue, Fang
• Format: Article
• Language: English
• Subjects: cardiac surgery; risk factors; stress-induced hyperglycemia; Systematic Review; systematic review and meta-analysis
• ISSN: 1530-6550; 2153-8174; 2153-8174
• DOI: 10.31083/RCM25485

To systematically evaluate risk factors for stress-induced hyperglycemia in patients without diabetes after cardiac surgery. Databases including CNKI, WanFang data, VIP, SinoMed, PubMed, Web of Science, Embase, and the Cochrane Library were searched using computer retrieval. The data were subjected to an in-depth meta-analysis using RevMan 5.4 and Stata 15.0 software. This study involved 11,645 postoperative cardiac surgery patients, including 8 case-control studies and 3 cohort studies, over which 18 risk factors were identified. The results of the meta-analysis indicated that statistically significant risk factors included age >65 years [odds ratios (OR) (95% CI ) = 3.47 (2.61-4.32)], female gender [OR (95%) = 1.54 (1.34-1.76)], combined heart valve and coronary artery bypass surgery [OR (95%) = 1.82 (1.23-2.70)], ejection fraction 2 hours [OR (95%) = 20.26 (17.03-23.48)] and history of cardiopulmonary bypass [OR (95%) = 1.24 (1.09-1.41)]. Current evidence suggests that there are key risk factors for postoperative stress hyperglycemia in patients without diabetes who have undergone cardiac surgery. These factors can help identify patients at a high risk of perioperative stress hyperglycemia during cardiac surgery. This evidence provides a basis for healthcare professionals to develop predictive management strategies for perioperative stress hyperglycemia in patients without diabetes. However, more high-quality studies are required to address the limitations of the current research. CRD42024479215, https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=479215.