Tertiary lymphoid structures' pattern and prognostic value in primary adenocarcinoma of jejunum and ileum

To date, there have been no reports on tertiary lymphoid structures (TLS) in primary adenocarcinoma of jejunum and ileum. In this study, we employed digital pathology image analysis software to classify and quantify TLS, and evaluated the maturity of TLS using immunohistochemistry. Molecular genetic...

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Bibliographic Details
Published in:World journal of surgical oncology 2024-09, Vol.22 (1), p.261-21, Article 261
Main Authors: Deng, Minying, Liu, Xin, Jiang, Yan, Luo, Rongkui, Xu, Lei, Zhang, Xiaolei, Su, Jieakesu, Xu, Chen, Hou, Yingyong
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - immunology
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adult
Aged
Analysis
B cells
Biomarkers, Tumor - analysis
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Care and treatment
Diagnosis
Female
Follow-Up Studies
Gastrointestinal cancer
Humans
Ileal Neoplasms - mortality
Ileal Neoplasms - pathology
Immunohistochemistry
Immunotherapy
Jejunal Neoplasms - pathology
Lymphoid tissue
Male
Medical examination
Medical research
Medicine, Experimental
Methods
Microsatellite Instability
Middle Aged
MSI
Patient compliance
PD-L1
Primary adenocarcinoma of jejunum and ileum
Prognosis
Retrospective Studies
Survival Rate
Tertiary Lymphoid Structures - immunology
Tertiary Lymphoid Structures - pathology
TLS
TMB
Citations: Items that this one cites
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Summary:To date, there have been no reports on tertiary lymphoid structures (TLS) in primary adenocarcinoma of jejunum and ileum. In this study, we employed digital pathology image analysis software to classify and quantify TLS, and evaluated the maturity of TLS using immunohistochemistry. Molecular genetics and immunotherapy biomarker detection were performed using next-generation sequencing technology, such as tumor mutational burden (TMB) and microsatellite instability (MSI). The aim of this study was to investigate the presence, location, maturity, association with immunotherapy biomarkers, and prognostic value of TLS in primary adenocarcinoma of jejunum and ileum. Compared to secondary follicle-like TLS (SFL-TLS), intra-tumoral TLS (IT-TLS) were more likely to manifest as early TLS (E-TLS) (P = 0.007). Compared to IT-TLS, SFL-TLS had a higher propensity to occur at the invasive margin (IM) (P = 0.032) and showed a trend towards being more prevalent at the tumor periphery (P = 0.057). In terms of immunotherapy biomarkers, there was a higher trend of IM-TLS density in PD-L1(22C3) score CPS 
ISSN:1477-7819
1477-7819
DOI:10.1186/s12957-024-03543-x