Occult Hepatitis C Infection Among Hemodialysis Patients: A Prevalence Study

AbstractIntroduction and aimOccult hepatitis C infection (OHCI) is the presence of HCV-RNA in the liver or peripheral blood mononuclear cells (PBMC) accompanying with negative serologic results. The aim of this study was to evaluate the prevalence of OHCI among Iranian chronic hemodialysis (HD) pati...

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Bibliographic Details
Published in:Annals of hepatology 2017-07, Vol.16 (4), p.510-513
Main Authors: Naghdi, Reza, Ranjbar, Mitra, Bokharaei-Salim, Farah, Keyvani, Hossein, Savaj, Shokoufeh, Ossareh, Shahrzad, Shirali, Amir, Mohammad-Alizadeh, Amir H
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers - blood
Cross-Sectional Studies
ESRD
Female
Gastroenterology and Hepatology
Hepacivirus - genetics
Hepatitis C - blood
Hepatitis C - diagnosis
Hepatitis C - epidemiology
Hepatitis C - virology
Hepatitis C virus
Humans
Iran - epidemiology
Kidney Failure, Chronic - diagnosis
Kidney Failure, Chronic - epidemiology
Kidney Failure, Chronic - therapy
Kidney transplant
Leukocytes, Mononuclear - virology
Liver disease
Male
Middle Aged
Peripheral Blood Mononuclear Cell (PBMC)
Prevalence
Renal Dialysis - adverse effects
Risk Assessment
Risk Factors
RNA, Viral - blood
Viral Load
Young Adult
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Summary:AbstractIntroduction and aimOccult hepatitis C infection (OHCI) is the presence of HCV-RNA in the liver or peripheral blood mononuclear cells (PBMC) accompanying with negative serologic results. The aim of this study was to evaluate the prevalence of OHCI among Iranian chronic hemodialysis (HD) patients. Material and methodsIn this cross sectional study 200 chronic HD patients with negative HCV antibody enrolled the study. Blood sample of patients were obtained, followed by Polymerase Chain reaction (PCR) testing for detection of HCV RNA. Patients with positive serum HCV RNA were considered as manifest hepatitis C infection (MHCI). However, patients with negative serum HCV RNA underwent further tests on PBMCs for detection of OHCI. ResultsSerum HCV RNA was positive in 2 (1%) patients whom considered as MHCI, and 6 (3.03%) patients had positive PBMC HCV RNA. ConclusionIn conclusion, chronic HD patients have been considered as a high risk group for hepatitis C infection. The results of this study suggest that these patients are also at risk for OHCI. Furthermore, evaluating PBMCs to detect HCV RNA would be a sensitive diagnostic method to find OHCI patients.
ISSN:1665-2681
DOI:10.5604/01.3001.0010.0277