Escin suppresses HMGB1‐induced overexpression of aquaporin‐1 and increased permeability in endothelial cells

Escin, a natural triterpene saponin mixture obtained from the horse chestnut tree (Aesculus hippocastanum), has been used for the treatment of chronic venous insufficiency (CVI), hemorrhoids, and edema. However, it is unclear how escin protects against endothelial barrier dysfunction induced by pro‐...

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Bibliographic Details
Published in:FEBS open bio 2019-05, Vol.9 (5), p.891-900
Main Authors: Chen, Changjun, Wang, Songgang, Chen, Jiying, Liu, Xiaolin, Zhang, Mengchen, Wang, Xi, Xu, Weihua, Zhang, Yayun, Li, Hao, Pan, Xin, Si, Meng
Format: Article
Language:English
Subjects:
Apoptosis
Aquaporin 1
Aquaporin 1 - genetics
Aquaporin 1 - metabolism
Aquaporins
barrier dysfunction
Cardiovascular Agents - pharmacology
Cell culture
Cell permeability
Edema
Endothelial cells
escin
Escin - pharmacology
Gene Expression Regulation - drug effects
Hemorrhoids
High mobility group protein 1
High mobility group proteins
HMGB1 protein
HMGB1 Protein - genetics
HMGB1 Protein - metabolism
Human Umbilical Vein Endothelial Cells - drug effects
Human Umbilical Vein Endothelial Cells - physiology
Humans
Inflammation
Permeability
Proteins
Saponins
Signal transduction
Toxicity
Varicose veins
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Summary:Escin, a natural triterpene saponin mixture obtained from the horse chestnut tree (Aesculus hippocastanum), has been used for the treatment of chronic venous insufficiency (CVI), hemorrhoids, and edema. However, it is unclear how escin protects against endothelial barrier dysfunction induced by pro‐inflammatory high mobility group protein 1 (HMGB1). Here, we report that escin can suppress (a) HMGB1‐induced overexpression of the aquaporin‐1 (AQP1) water channel in endothelial cells and (b) HMGB1‐induced increases in endothelial cell permeability. This is the first report that escin inhibits AQP1 and alleviates barrier dysfunction in HMGB1‐induced inflammatory response. Aquaporin (AQP) inhibitors may provide a new approach for the treatment of many diseases. High mobility group protein 1 (HMGB1), an important pro‐inflammatory mediator, was used to increase the expression of AQP1 and induce barrier dysfunction in endothelial cells. The results suggest that escin may reverse this pathological change, and future studies may help us understand the underlying mechanisms.
ISSN:2211-5463
2211-5463
DOI:10.1002/2211-5463.12622