Addressing the need for genetic cancer risk assessment in Mexico: From establishment of a formal program to delivery innovation and expansion

The purpose of this manuscript is to show the process of the establishment and adaptation of an oncogenetics program in Mexico. The oncogentics program at the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán was established as a traditional in-person service and adapted to include...

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Published in:Genetics in Medicine Open 2024, Vol.2, p.101874, Article 101874
Main Authors: Chávarri-Guerra, Yanin, Rodríguez-Olivares, José Luis, Ramírez-González, Alfredo, Moreno-Mirón, José Manuel, Lagunas-Medina, Alex, Peñafort-Zamora, José Carlos, Arteaga-Vázquez, Jazmin, Quintero-Beuló, Gregorio, Sánchez-Reyes, Roberto, Weitzel, Jeffrey N.
Format: Article
Language:English
Subjects:
Genetic cancer risk assessment
Hereditary cancer
Latin America
Low- and middle-income countries
Telemedicine
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Summary:The purpose of this manuscript is to show the process of the establishment and adaptation of an oncogenetics program in Mexico. The oncogentics program at the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán was established as a traditional in-person service and adapted to include telemedicine counseling to expand services to other hospitals and persists as a mixed counseling model with research/commercial genetic testing. A total of 2222 participants were included with a median age of 47 years and 77.6% were women; 64% and 36% were enrolled in person and by phone, respectively; 91.1% had research testing, 4.7% commercial testing, 2% complementary pharma testing, and 2.1% had more than 1 testing. Results disclosure was by phone for 49.6%, in person for 43.3%, and by videocall for 7.1% of the cases. Cascade testing proportion was similar in both groups (88%), and 14.8% probands and 40.8% family members had a positive result for a pathogenic cancer susceptibility gene variant. Our results demonstrated that genetic cancer risk assessment is feasible in limited resources settings and provide evidence that telemedicine is effective and can be used as an alternative in real-world populations. Our model could be adapted and potentially replicated in other institutions and countries that face similar barriers for health care.
ISSN:2949-7744
2949-7744
DOI:10.1016/j.gimo.2024.101874