Occurrence of colorectal aberrant crypt foci depending on age and dietary patterns of patients

Aberrant crypt foci (ACF) are commonly considered the early pre-cancerous lesions that can progress to colorectal cancer (CRC). The available literature data reveal that age, dietary factors and lifestyle can affect the development of several dozen percentages of malignant tumours, including CRC. In...

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Bibliographic Details
Published in:BMC cancer 2018-02, Vol.18 (1), p.213-213, Article 213
Main Authors: Kowalczyk, Marek, Orłowski, Marcin, Siermontowski, Piotr, Mucha, Dariusz, Zinkiewicz, Krzysztof, Kurpiewski, Waldemar, Zieliński, Ewa, Kowalczyk, Iwona, Pedrycz, Agnieszka
Format: Article
Language:English
Subjects:
Aberrant crypt foci
Aberrant Crypt Foci - diagnosis
Aberrant Crypt Foci - epidemiology
Aberrant Crypt Foci - etiology
Adenoma
Adult
Age Distribution
Age Factors
Aged
Aged, 80 and over
Biopsy
Colonoscopy
Colorectal cancer
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - etiology
Development and progression
Diet
Dietary patterns
Dietary supplements
Female
Food habits
Health aspects
Humans
Large intestine
Life Style
Male
Middle Aged
Precancerous Conditions
Risk Assessment
Risk Factors
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Summary:Aberrant crypt foci (ACF) are commonly considered the early pre-cancerous lesions that can progress to colorectal cancer (CRC). The available literature data reveal that age, dietary factors and lifestyle can affect the development of several dozen percentages of malignant tumours, including CRC. In the present study, an attempt was made to assess the incidence and growth dynamics of ACF and to determine whether the type of diet affected the development and number of AFC. Colonoscopy combined with rectal mucosa staining with 0.25% methylene blue was performed in 131 patients. On the day of examination, each patient completed a questionnaire regarding epidemiological data. According to their numbers, colorectal ACF were divided into three groups. The findings were analysed statistically. The Student's t test and the U test were applied in order to determine the significance of differences of means and frequency of events in both groups. Statistica 7.1 and Excel 2010 were used. The single ACF occur in the youngest individuals (ACF 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-018-4100-8