Endemic carbapenem-resistant Pseudomonas aeruginosa with acquired metallo-beta-lactamase determinants in European hospital

Acquired metallo-beta-lactamases (MBLs) can confer broad-spectrum beta-lactam resistance (including carbapenems) not reversible by conventional beta-lactamase inhibitors and are emerging resistance determinants of remarkable clinical importance. In 2001, multidrug-resistant Pseudomonas aeruginosa ca...

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Bibliographic Details
Published in:Emerging infectious diseases 2004-03, Vol.10 (3), p.535-538
Main Authors: Lagatolla, Cristina, Tonin, Enrico A, Monti-Bragadin, Carlo, Dolzani, Lucilla, Gombac, Francesca, Bearzi, Claudia, Edalucci, Elisabetta, Gionechetti, Fabrizia, Rossolini, Gian Maria
Format: Article
Language:English
Subjects:
bacterial
bacterial typing
beta-Lactam Resistance - drug effects
beta-Lactam Resistance - genetics
carbapenem-hydrolyzing beta-lactamase
Carbapenems - pharmacology
Dispatch
drug resistance
Drug Resistance - genetics
Europe
Genotype
Humans
multiple
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - genetics
Pseudomonas aeruginosa - isolation & purification
Random Amplified Polymorphic DNA Technique
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Summary:Acquired metallo-beta-lactamases (MBLs) can confer broad-spectrum beta-lactam resistance (including carbapenems) not reversible by conventional beta-lactamase inhibitors and are emerging resistance determinants of remarkable clinical importance. In 2001, multidrug-resistant Pseudomonas aeruginosa carrying bla(VIM) MBL genes were found to be widespread (approximately 20% of all P. aeruginosa isolates and 70% of the carbapenem-resistant isolates) at Trieste University Hospital. Clonal diversity and heterogeneity of resistance determinants (either bla(VIM-1)-like or bla(VIM-2)-like) were detected among MBL producers. This evidence is the first that acquired MBLs can rapidly emerge and establish a condition of endemicity in certain epidemiologic settings.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1003.020799