Inverse association of fat mass, but not lean mass, with glycated albumin in hemodialysis patients with or without diabetes mellitus

• Published in: Renal failure 2019-01, Vol.41 (1), p.808-813
• Main Authors: Miyawaki, Jiro, Okuno, Senji, Mori, Katsuhito, Nishio, Eriko, Norimine, Kyoko, Kurajoh, Masafumi, Yamakawa, Tomoyuki, Shoji, Shigeichi, Inaba, Masaaki
• Format: Article
• Language: English
• Subjects: Abdominal Fat - diagnostic imaging; Absorptiometry; Absorptiometry, Photon; Aged; Albumin; Blood Glucose - analysis; Blood Glucose - drug effects; Body Composition; Body fat; Body Mass Index; Clinical Study; Cross-Sectional Studies; Diabetes; Diabetes Complications - blood; Diabetes Complications - etiology; Diabetes Complications - prevention & control; Diabetes mellitus; Dual energy X-ray absorptiometry; Erythropoiesis; fat mass; Female; Glucose; Glycated albumin; Hemodialysis; Hemoglobin; Humans; Hypoglycemic Agents - pharmacology; Hypoglycemic Agents - therapeutic use; Male; Middle Aged; Multiple regression analysis; Renal Dialysis - adverse effects; Serum Albumin - analysis
• ISSN: 0886-022X; 1525-6049
• DOI: 10.1080/0886022X.2019.1659819

Background: Glycated albumin (GA), which is independent of anemia and/or use of erythropoiesis-stimulating agents, might provide a more precise measure than glycated hemoglobin (HbA1c) in hemodialysis patients. The present study examines whether body composition is associated with GA besides glycemic control in hemodialysis patients. Methods: This study included 90 hemodialysis patients with diabetes mellitus (DM) and 86 hemodialysis patients without DM. We examined blood parameters after an overnight fast and body fat and lean mass using dual X-ray absorptiometry 21-24 h after completing the dialysis session. Results: The mean body mass index (BMI) was 22.0 kg/m 2 . BMI and truncal fat mass were significantly higher, and total fat mass tended to be higher in hemodialysis patients with DM than in those without DM. GA exhibited inverse correlations with BMI, total lean mass, total fat mass, and truncal fat mass in hemodialysis patients with and without DM; however, there was a lack of correlation with total lean mass in patients without DM. In multiple regression analysis including total fat mass and total lean mass simultaneously as independent variables, total fat mass (with DM: β = -0.322, p = .006) (without DM: β = -0.391, p