New Insights from Metabolomics in Pediatric Renal Diseases

Renal diseases in childhood form a spectrum of different conditions with potential long-term consequences. Given that, a great effort has been made by researchers to identify candidate biomarkers that are able to influence diagnosis and prognosis, in particular by using omics techniques (e.g., metab...

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Bibliographic Details
Published in:Children (Basel) 2022-01, Vol.9 (1), p.118
Main Authors: Riccio, Simona, Valentino, Maria Sole, Passaro, Antonio Paride, Izzo, Marica, Guarino, Stefano, Miraglia Del Giudice, Emanuele, Marzuillo, Pierluigi, Di Sessa, Anna
Format: Article
Language:English
Subjects:
Biomarkers
children
Chromatography
Congenital diseases
disease
Fatty acids
Gestational age
Glycoproteins
Heart surgery
Intensive care
Kidney diseases
Mass spectrometry
Metabolism
Metabolites
metabolomics
Mortality
Newborn babies
NMR
Nuclear magnetic resonance
Pediatrics
Proteins
renal
Review
Scientific imaging
Sepsis
Urine
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Summary:Renal diseases in childhood form a spectrum of different conditions with potential long-term consequences. Given that, a great effort has been made by researchers to identify candidate biomarkers that are able to influence diagnosis and prognosis, in particular by using omics techniques (e.g., metabolomics, lipidomics, genomics, and transcriptomics). Over the past decades, metabolomics has added a promising number of 'new' biomarkers to the 'old' group through better physiopathological knowledge, paving the way for insightful perspectives on the management of different renal diseases. We aimed to summarize the most recent omics evidence in the main renal pediatric diseases (including acute renal injury, kidney transplantation, chronic kidney disease, renal dysplasia, vesicoureteral reflux, and lithiasis) in this narrative review.
ISSN:2227-9067
2227-9067
DOI:10.3390/children9010118