The Effects of Riluzole on Cisplatin-induced Ototoxicity

• Published in: International Archives of Otorhinolaryngology 2019-07, Vol.23 (3), p.e267-e275
• Main Authors: Üstün Bezgin, Selin, Uygur, Kadir Kemal, Gökdoğan, Çağıl, Elmas, Çiğdem, Göktaş, Güleser
• Format: Article
• Language: English
• Subjects: auditory brainstem response; cisplatin; Original Research; OTORHINOLARYNGOLOGY; ototoxicity; riluzole; transmission electron microscopy
• ISSN: 1809-9777; 1809-4864; 1809-4864
• DOI: 10.1055/s-0038-1676654

Abstract Introduction  Riluzole (2-amino-6-trifluoromethoxy benzothiazole) is known as a neuroprotective, antioxidant, antiapoptotic agent. It may have beneficial effects on neuronal cell death due to cisplatin-induced ototoxicity. Objective  To evaluate the effect of riluzole on cisplatin-induced ototoxicity in guinea pigs. Methods  Twenty-four guinea pigs, studied in three groups, underwent auditory brainstem response evaluation using click and 8 kHz tone burst stimuli. Subsequently, 5 mg/kg of cisplatin were administered to all animals for 3 days intraperitoneally (i.p.) to induce ototoxicity. Half an hour prior to cisplatin, groups 1, 2 and 3 received 2 ml of saline i.p., 6 mg/kg of riluzole hydrochloride i.p., and 8 mg/kg of riluzole hydrochloride i.p., respectively, for 3 days. The auditory brainstem responses were repeated 24 hours after the last drug administration. The cochleae were analyzed by transmission electron microscopy (TEM). Results  After drug administiration, for 8,000 Hz stimulus, group 1 had significantly higher threshold shifts when compared with groups 2 ( p