Potential impact of a nine-valent vaccine in human papillomavirus related cervical disease

Information on human papillomavirus (HPV) type distribution is necessary to evaluate the potential impact of current and future HPV vaccines. We estimated the relative contribution (RC) to invasive cervical cancer (ICC) and precancerous cervical lesions of the nine HPV types (HPV 6/11/16/18/31/33/45...

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Bibliographic Details
Published in:Infectious agents and cancer 2012-12, Vol.7 (1), p.38-38, Article 38
Main Authors: Serrano, Beatriz, Alemany, Laia, Tous, Sara, Bruni, Laia, Clifford, Gary M, Weiss, Thomas, Bosch, Francesc Xavier, de Sanjosé, Silvia
Format: Article
Language:English
Subjects:
Adenocarcinoma
Age
Analysis
Cervical cancer
Cervix
Development and progression
Epidemiology
Genotype
Geriatrics
Human papillomavirus
Human papillomavirus vaccines
Invasiveness
Medical research
Medicine, Experimental
Papillomavirus infections
Papillomaviruses
Population growth
Reviews
Risk factors
Squamous cell carcinoma
Vaccines
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Summary:Information on human papillomavirus (HPV) type distribution is necessary to evaluate the potential impact of current and future HPV vaccines. We estimated the relative contribution (RC) to invasive cervical cancer (ICC) and precancerous cervical lesions of the nine HPV types (HPV 6/11/16/18/31/33/45/52/58) included in an HPV vaccine currently under development. Estimations on ICC were based on an international study of 8,977 HPV positive cases and estimations on precancerous cervical lesions were extracted from a published meta-analysis including 115,789 HPV positive women. Globocan 2008 and 2010 World Population Prospects were used to estimate current and future projections of new ICC cases. RC of the 9 HPV types in ICC was 89.4%, with 18.5% of cases positive for HPV 31/33/45/52/58. Regional variations were observed. RCs varied by histology, ranging between 89.1% in squamous cell carcinomas (SCC) and 95.5% in adenocarcinomas (ADC). HPV 16/18/45 were detected in 94.2% of ADC. RC of the 9 types altogether decreased with age (trend test p 
ISSN:1750-9378
1750-9378
DOI:10.1186/1750-9378-7-38