Genome-wide dynamic network analysis reveals the potential genes for MeJA-induced growth-to-defense transition

Methyl jasmonate (MeJA), which has been identified as a lipid-derived stress hormone, mediates plant resistance to biotic/abiotic stress. Understanding MeJA-induced plant defense provides insight into how they responding to environmental stimuli. In this work, the dynamic network analysis method was...

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Bibliographic Details
Published in:BMC plant biology 2021-10, Vol.21 (1), p.1-450, Article 450
Main Authors: Wang, Tengfei, Zhang, Xiujun
Format: Article
Language:English
Subjects:
Biomarkers
Defense mechanisms
Dynamic network biomarker (DNB)
Environmental effects
Functional analysis
Gene expression
Genes
Genetic aspects
Genomes
Growth (Plants)
Growth-to-defense transition
Hardiness
Influence
Jasmonates
Lipids
Metabolism
Methods
Methyl jasmonate
Methyl jasmonate (MeJA)
Network analysis
Phase transitions
Physiology
Plant defenses
Plant growth
Plant resistance
Plants
Proteins
Standard deviation
Stimuli
Tipping point
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Summary:Methyl jasmonate (MeJA), which has been identified as a lipid-derived stress hormone, mediates plant resistance to biotic/abiotic stress. Understanding MeJA-induced plant defense provides insight into how they responding to environmental stimuli. In this work, the dynamic network analysis method was used to quantitatively identify the tipping point of growth-to-defense transition and detect the associated genes. As a result, 146 genes were detected as dynamic network biomarker (DNB) members and the critical defense transition was identified based on dense time-series RNA-seq data of MeJA-treated Arabidopsis thaliana. The GO functional analysis showed that these DNB genes were significantly enriched in defense terms. The network analysis between DNB genes and differentially expressed genes showed that the hub genes including SYP121, SYP122, WRKY33 and MPK11 play a vital role in plant growth-to-defense transition. Based on the dynamic network analysis of MeJA-induced plant resistance, we provide an important guideline for understanding the growth-to-defense transition of plants' response to environment stimuli. This study also provides a database with the key genes of plant defense induced by MeJA.
ISSN:1471-2229
1471-2229
DOI:10.1186/s12870-021-03185-1