Beer promotes differentiation and mineralization of human osteoblastic cells: Role of silicon

[Display omitted] •Beer is the major contributor to silicon intake in the Western diet.•Beer enhances cells viability and proliferation compared to orthosilicic acid treatment.•Beer is the best effective inducer of mineralization compared to orthosilicic acid treatment.•Beer is the best inducer of E...

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Published in:Journal of functional foods 2019-03, Vol.54, p.109-118
Main Authors: Millucci, Lia, Minetti, Mariagiulia, Orlandini, Maurizio, Braconi, Daniela, Schiavone, Maria Lucia, Galderisi, Silvia, Marzocchi, Barbara, Spiga, Ottavia, Rappuoli, Roberto, Spreafico, Adriano, Perretti, Giuseppe, Bernardini, Giulia, Santucci, Annalisa
Format: Article
Language:English
Subjects:
Beer
Bone
Nutraceutical
Orthosilicic acid
Osteoarticular diseases
Silicon
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Summary:[Display omitted] •Beer is the major contributor to silicon intake in the Western diet.•Beer enhances cells viability and proliferation compared to orthosilicic acid treatment.•Beer is the best effective inducer of mineralization compared to orthosilicic acid treatment.•Beer is the best inducer of ECM production compared to orthosilicic acid treatment.•Beer promote osteoblast activity and bone mineralization more than orthosilicic acid. Silicon (Si) is an essential element for bone metabolism and beer is one of the richest sources of orthosilicic acid (OSA), the readily bioavailable form of Si. In this work, we compared the in vitro pro-anabolic effects on human osteoblastic cells of OSA and beer. We determined the optimal OSA concentration range positively affecting cell viability, proliferation, osteoblastic differentiation and collagen synthesis. Even more positive effects were obtained treating cells with beer containing the optimal dose of silicon, since beer also promoted cells differentation increasing alkaline phosphatase activity, mineral nodules formation, collagen and glycosaminoglycans synthesis and nitric oxide release. This study showed, for the first time, that beer has evident beneficial effects towards osteoblastic functionality, in respect to OSA alone and this may probably be ascribed to its interrelationship with other elements present in the whole beverage, thus supporting the potential use of beer as nutraceutical to prevent bone omeostastasis unbalance.
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2019.01.023