Immediate outcome prognostic value of plasma factors in patients with acute ischemic stroke after intravenous thrombolytic treatment

In the present study, we explored multiple plasma factors to predict the outcomes of patients with AIS after IVT. Fifty AIS patients who received IVT with alteplase were recruited and divided into two groups according to their NIHSS scores. Serum from all subjects was collected to quantitatively ana...

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Bibliographic Details
Published in:BMC neurology 2022-09, Vol.22 (1), p.1-359, Article 359
Main Authors: Lu, Huanhuan, Li, Siyi, Zhong, Xin, Huang, Shuxuan, Jiao, Xue, He, Guoyong, Jiang, Bingjian, Liu, Yuping, Gao, Zhili, Wei, Jinhong, Lin, Yushen, Chen, Zhi, Li, Yanhua
Format: Article
Language:English
Subjects:
Acute ischemic stroke
Analysis
Biomarkers
Blood pressure
Cardiac arrhythmia
Cardiovascular disease
Diabetes
Enzyme-linked immunosorbent assay
Gelatinase B
Hemorrhage
Hyperlipidemia
Hypertension
Interleukin 6
Intravenous administration
Intravenous therapy
Intravenous thrombolysis
Ischemia
NIHSS score
Normal distribution
Patient outcomes
Patients
Plasma
Plasma cells
Plasma factors
Prevention
Prognosis
Risk factors
Statistical analysis
Stroke
Stroke (Disease)
Thrombolysis
Tumors
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Summary:In the present study, we explored multiple plasma factors to predict the outcomes of patients with AIS after IVT. Fifty AIS patients who received IVT with alteplase were recruited and divided into two groups according to their NIHSS scores. Serum from all subjects was collected to quantitatively analyze the levels of different plasma factors, IL-6, MMP-9, ADAMTS13, TNC, GSN and TRX, using Luminex assays or ELISA measurements. Compared with the levels assessed at the onset of AIS, the levels of MMP-9 ( P  
ISSN:1471-2377
1471-2377
DOI:10.1186/s12883-022-02898-6