Seasonal variations in renal biopsy numbers and primary glomerular disease features based on the Japan renal biopsy registry

We analyzed the seasonal variations in the number of renal biopsies and clinical characteristics of primary glomerular disease in Japan using the Japan Renal Biopsy Registry (J-RBR). We retrospectively collected clinical and pathological data of patients with primary glomerular disease who were regi...

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Bibliographic Details
Published in:Scientific reports 2023-03, Vol.13 (1), p.5123-5123, Article 5123
Main Authors: Kanzaki, Go, Tsuboi, Nobuo, Yokoo, Takashi, Uesugi, Noriko, Furuichi, Kengo, Shimizu, Akira, Sugiyama, Hitoshi, Sato, Hiroshi, Yokoyama, Hitoshi
Format: Article
Language:English
Subjects:
692/4022
692/4022/1585
Biopsy
Blood pressure
Glomerulonephritis
Glomerulonephritis - pathology
Glomerulonephritis, IGA - pathology
Glomerulonephritis, Membranous - pathology
Humanities and Social Sciences
Humans
Immunoglobulin A
Japan - epidemiology
Kidney - pathology
Kidneys
Membranous nephropathy
multidisciplinary
Nephropathy
Nephrosis, Lipoid - pathology
Nephrotic syndrome
Registries
Retrospective Studies
Science
Science (multidisciplinary)
Seasonal variations
Seasons
Winter
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Summary:We analyzed the seasonal variations in the number of renal biopsies and clinical characteristics of primary glomerular disease in Japan using the Japan Renal Biopsy Registry (J-RBR). We retrospectively collected clinical and pathological data of patients with primary glomerular disease who were registered in the J-RBR between 2007 and 2018. Immunoglobulin A nephropathy (IgAN), minimal change nephrotic syndrome (MCNS), membranous nephropathy (MN), and postinfectious acute glomerulonephritis (PIAGN) constituted the four major glomerular disorders included in this study (total, 13,989; IgAN, 9121; MCNS, 2298; MN, 2447; and PIAGN, 123). The number of patients with IgAN or MCNS was higher during summer. However, no overt seasonal variations were observed in patients with MN or PIAGN. Subgroup analyses suggested that in the patients with IgAN, more renal biopsies of severe cases were performed during winter, probably owing to age and blood pressure. Furthermore, more renal biopsies of severe cases were performed during spring and winter in patients with MCNS even after adjusting for the abovementioned host factors. This study suggests that seasonal factors influence the decision to perform renal biopsy as well as the pathogenesis of primary glomerular disease. Thus, our findings may provide important insights regarding the pathophysiology of primary glomerular disease.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-32182-7