Presence of sarcopenia in asthma-COPD overlap syndrome may be a risk factor for decreased bone-mineral density, unlike asthma: Korean National Health and Nutrition Examination Survey (KNHANES) IV and V (2008-2011)

Sarcopenia and decreased bone-mineral density (BMD) are common in elderly people, and are major comorbidities of obstructive airway disease (OAD). However, the relationship between sarcopenia and BMD in each OAD phenotype, especially asthma-COPD overlap syndrome (ACOS), is not yet clear. We aimed to...

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Bibliographic Details
Published in:International journal of chronic obstructive pulmonary disease 2017-01, Vol.12, p.2355-2362
Main Authors: Lee, Dong-Won, Jin, Hyun-Jung, Shin, Kyeong-Cheol, Chung, Jin-Hong, Lee, Hyoung-Woo, Lee, Kwan-Ho
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Age
Aged
Asthma
Asthma - diagnosis
Asthma - epidemiology
Asthma - physiopathology
Asthma-COPD overlap syndrome
Body mass index
Bone Density
Bone mineral density
Chonic obstructive pulmonary disease
Chronic obstructive pulmonary disease
Cross-Sectional Studies
Disease control
Female
Genotype & phenotype
Humans
Lung - physiopathology
Male
Middle Aged
Musculoskeletal system
Nutrition
Nutrition Surveys
Older people
Original Research
Osteoporosis
Osteoporosis - diagnosis
Osteoporosis - epidemiology
Osteoporosis - physiopathology
Phenotype
Phosphatase
Population
Prevalence
Public health
Pulmonary Disease, Chronic Obstructive - diagnosis
Pulmonary Disease, Chronic Obstructive - epidemiology
Pulmonary Disease, Chronic Obstructive - physiopathology
Quality of life
Questionnaires
Republic of Korea - epidemiology
Retrospective Studies
Risk Factors
Sarcopenia
Sarcopenia - diagnosis
Sarcopenia - epidemiology
Sarcopenia - physiopathology
Spirometry
Syndrome
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Description
Summary:Sarcopenia and decreased bone-mineral density (BMD) are common in elderly people, and are major comorbidities of obstructive airway disease (OAD). However, the relationship between sarcopenia and BMD in each OAD phenotype, especially asthma-COPD overlap syndrome (ACOS), is not yet clear. We aimed to evaluate differences in BMD according to the presence of sarcopenia in each OAD phenotype. Among the research subjects in KNHANES IV and V (2008-2011), 5,562 were ≥50 years old and underwent qualified spirometry and dual-energy X-ray absorptiometry. A total of 947 subjects were included in the study: 89 had asthma, 748 COPD, and 110 ACOS. In the COPD and ACOS phenotypes, T-scores were lower in the sarcopenia group than the nonsarcopenia group. Prevalence rates of osteopenia and osteoporosis were higher in the sarcopenia group than the nonsarcopenia group. (
ISSN:1178-2005
1176-9106
1178-2005
DOI:10.2147/COPD.S138497